Gavrilovskaya I, Apekina N, Okulova N, Demina V, Bernshtein A, Myasnikov Y
Russian Academy of Medical Science (RAMS), Institute of Poliomyelitis and Viral Encephalitides, Moscow.
Arch Virol. 1993;132(3-4):359-67. doi: 10.1007/BF01309545.
An immunoglobulin G avidity assay was used to determine recent and past hantavirus infection in bank voles (Clethrionomys glareolus). Sera of experimentally infected bank voles were studied at different time intervals. The avidity of specific IgG increased over time after infection. This experimental data were used to estimate the time after onset of hantavirus infection in naturally infected bank voles caught in an endemic area. The possibility to discriminate between recently infected animals and animals infected some time ago is important since the proportion of recently infected bank voles represents the intensity of the epizootic which in turn correlates to the risk of humans to contract the disease.
采用免疫球蛋白G亲和力检测法来确定林姬鼠（黄毛鼠）近期和既往的汉坦病毒感染情况。对实验感染林姬鼠的血清在不同时间间隔进行研究。感染后，特异性IgG的亲和力随时间增加。该实验数据用于估计在疫区捕获的自然感染林姬鼠感染汉坦病毒后的发病时间。区分近期感染动物和一段时间前感染动物的可能性很重要，因为近期感染林姬鼠的比例代表了 epizootic 的强度，而 epizootic 又与人类感染该疾病的风险相关。
