血清对淋巴细胞有丝分裂原刺激反应的比较抑制作用。

Comparative inhibitory effects of serum on lymphocyte responses to mitogenic stimulation.

作者信息

Hsu C C

出版信息

Int Arch Allergy Appl Immunol. 1976;50(1):14-26. doi: 10.1159/000231476.

Abstract

The effects of sera from pregnant women, human umbilical cords and nonpregnant healthy control individuals on human lymphocyte responses to phytohemagglutinin (PHA), pokeweed mitogen (PWM) and allogeneic lymphocytes (MLR) are described. Maternal sera invariably inhibited lymphocyte responses to PHA. In MLR and PWM-stimulated lymphocyte responses, however, some maternal sera had pronounced inhibitory effect while other maternal sera had none. Similar dissociation of inhibitory effects of lymphocyte responses to PHA and to PWM or in MLR was noted in some cord sera but not in the control sera we studied. The observations may reflect different serum factors impinging upon different lymphocyte subpopulations responsive to different mitogens. Preliminary attempts to relate the serum inhibitory effects to various serum components revealed that inhibition of MLR appeared to correlate with increases in alpha-2-globulins and beta-globulins. In contrast, inhibition of PHA responses was not similarly related to any one or two specific serum constituents.

摘要

本文描述了孕妇血清、人脐带血清以及非孕健康对照个体血清对人淋巴细胞对植物血凝素（PHA）、商陆有丝分裂原（PWM）和同种异体淋巴细胞（混合淋巴细胞反应，MLR）反应的影响。母体血清总是会抑制淋巴细胞对PHA的反应。然而，在混合淋巴细胞反应和PWM刺激的淋巴细胞反应中，一些母体血清具有明显的抑制作用，而其他母体血清则没有。在一些脐带血清中也观察到淋巴细胞对PHA和PWM反应或在混合淋巴细胞反应中的抑制作用存在类似的分离现象，但在我们研究的对照血清中未观察到。这些观察结果可能反映了不同的血清因子作用于对不同有丝分裂原产生反应的不同淋巴细胞亚群。将血清抑制作用与各种血清成分相关联的初步尝试表明，混合淋巴细胞反应的抑制似乎与α-2球蛋白和β-球蛋白的增加相关。相比之下，PHA反应的抑制与任何一种或两种特定血清成分没有类似的关联。