School of Pharmacy, International Medical University, No. 126 Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
Masonic Medical Research Institute, 2150 Bleecker St, Utica, NY 13501, USA.
Int J Environ Res Public Health. 2020 May 11;17(9):3326. doi: 10.3390/ijerph17093326.
Hand hygiene is of utmost importance as it may be contaminated easily from direct contact with airborne microorganism droplets from coughs and sneezes. Particularly in situations like pandemic outbreak, it is crucial to interrupt the transmission chain of the virus by the practice of proper hand sanitization. It can be achieved with contact isolation and strict infection control tool like maintaining good hand hygiene in hospital settings and in public. The success of the hand sanitization solely depends on the use of effective hand disinfecting agents formulated in various types and forms such as antimicrobial soaps, water-based or alcohol-based hand sanitizer, with the latter being widely used in hospital settings. To date, most of the effective hand sanitizer products are alcohol-based formulations containing 62%-95% of alcohol as it can denature the proteins of microbes and the ability to inactivate viruses. This systematic review correlated with the data available in Pubmed, and it will investigate the range of available hand sanitizers and their effectiveness as well as the formulation aspects, adverse effects, and recommendations to enhance the formulation efficiency and safety. Further, this article highlights the efficacy of alcohol-based hand sanitizer against the coronavirus.
手卫生至关重要，因为它可能会因直接接触咳嗽和打喷嚏产生的空气传播微生物飞沫而受到污染。特别是在大流行爆发的情况下，通过正确的手部消毒来打断病毒的传播链至关重要。这可以通过接触隔离和严格的感染控制工具来实现，例如在医院和公共场所保持良好的手部卫生。手部消毒的成功完全取决于使用有效的手部消毒剂，这些消毒剂以各种类型和形式配制，例如抗菌肥皂、水基或酒精基手部消毒剂，后者在医院环境中广泛使用。迄今为止，大多数有效的手部消毒剂产品都是含有 62%-95%酒精的酒精基配方，因为它可以使微生物的蛋白质变性，并且能够使病毒失活。本系统评价与 Pubmed 中可用的数据相关联，它将调查现有的手部消毒剂的范围及其有效性以及配方方面、不良反应和建议，以提高配方的效率和安全性。此外，本文还强调了酒精基手部消毒剂对冠状病毒的功效。
