Savarino S J
Enteric Diseases Program, Naval Medical Research Institute, Bethesda, MD 20889.
Trans R Soc Trop Med Hyg. 1993 Dec;87 Suppl 3:49-53. doi: 10.1016/0035-9203(93)90539-3.
Despite a great expansion in our knowledge of the causative agents of infectious diarrhoea over the past 20 years, a significant proportion of diarrhoeal cases remains undiagnosed. Enteroadherent Escherichia coli are a relatively recently identified group of enteric bacteria which have been implicated as diarrhoeal pathogens. These organisms, defined by their ability to adhere to human epithelial-derived tissue culture cells, have been closely studied over the past 10 years and appear to be quite heterogeneous. This review summarizes our current understanding of enteroadherent E. coli and the recognized subgroups. At least 3 distinct tissue culture cell adherence patterns have been recognized: localized adherence, characteristic of enteropathogenic E. coli, diffuse adherence, and aggregative adherence. Studies examining the epidemiological and pathogenic significance of the latter 2 groups, so-called diffusely adhering E. coli and enteroaggregative E. coli, are discussed in detail.
尽管在过去20年里我们对感染性腹泻病原体的认识有了很大扩展，但仍有相当一部分腹泻病例未得到诊断。肠黏附性大肠杆菌是一组相对较新发现的肠道细菌，被认为是腹泻病原体。这些细菌通过其黏附于人上皮来源的组织培养细胞的能力来定义，在过去10年里得到了深入研究，且似乎具有很大的异质性。本综述总结了我们目前对肠黏附性大肠杆菌及其公认亚组的认识。至少已识别出3种不同的组织培养细胞黏附模式：局部黏附，这是肠致病性大肠杆菌的特征；弥漫性黏附；以及集聚性黏附。本文将详细讨论对后两组细菌，即所谓的弥漫性黏附性大肠杆菌和肠集聚性大肠杆菌的流行病学和致病意义的研究。
