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本文引用的文献

1
Human retinal pigment epithelial cells in tissue culture: a means of studying inherited retinal diseases.组织培养中的人视网膜色素上皮细胞：一种研究遗传性视网膜疾病的方法。
Birth Defects Orig Artic Ser. 1982;18(6):101-18.
2
Regional distribution of lysosomal enzymes in the retina and choroid of human eyes.人眼视网膜和脉络膜中溶酶体酶的区域分布。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(4):269-73. doi: 10.1007/BF00455034.
3
The relative proportions of lysosomal enzyme activities in bovine retinal pigment epithelium.牛视网膜色素上皮中溶酶体酶活性的相对比例。
Exp Eye Res. 1983 Jan;36(1):151-8. doi: 10.1016/0014-4835(83)90098-2.
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Altered phosphoglycerate kinase in aging rats.衰老大鼠中磷酸甘油酸激酶的改变
J Biol Chem. 1980 Jun 10;255(11):5043-50.
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Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.
Invest Ophthalmol Vis Sci. 1980 Aug;19(8):864-9.
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Participation of the retinal pigment epithelium in the rod outer segment renewal process.视网膜色素上皮在视杆细胞外段更新过程中的参与。
J Cell Biol. 1969 Aug;42(2):392-403. doi: 10.1083/jcb.42.2.392.
7
Development of the human retinal pigment epithelium and the posterior segment.人类视网膜色素上皮及眼后段的发育
Arch Ophthalmol. 1969 Mar;81(3):383-94. doi: 10.1001/archopht.1969.00990010385017.
8
The degradation of the photoreceptor outer segment within the pigment epithelial cell of rat retina.大鼠视网膜色素上皮细胞内光感受器外段的降解。
J Electron Microsc (Tokyo). 1970;19(1):85-99.
9
Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies.大鼠脑神经元的电子显微镜研究。酸性磷酸酶的定位及脂褐质小体的形成方式。
J Ultrastruct Res. 1972 Jan;38(1):1-15. doi: 10.1016/s0022-5320(72)90080-9.
10
Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.人眼视网膜色素上皮脂褐素、黑色素及脉络膜黑色素
Invest Ophthalmol Vis Sci. 1986 Feb;27(2):145-52.

人类视网膜色素上皮中溶酶体酶的区域差异及与年龄相关的变化

Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium.

作者信息

Boulton M, Moriarty P, Jarvis-Evans J, Marcyniuk B

机构信息

Department of Ophthalmology, University of Manchester.

出版信息

Br J Ophthalmol. 1994 Feb;78(2):125-9. doi: 10.1136/bjo.78.2.125.

DOI:10.1136/bjo.78.2.125
PMID:8123620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC504714/
Abstract

In this study the activities of two lysosomal enzymes in retinal pigment epithelial (RPE) cells isolated from three regions of the human fundus were examined: the macula, the nasal midzone, and the periphery. The results obtained showed that the activities of acid phosphatase and cathepsin D were significantly higher in the RPE cells derived from the macular region when compared with those in the periphery. The values for the midzone appeared to be intermediate between the other two regions. Furthermore, the overall activity of both enzymes increased as a function of age.

摘要

在本研究中，检测了从人眼底三个区域分离的视网膜色素上皮（RPE）细胞中两种溶酶体酶的活性：黄斑区、鼻中区和周边区。所得结果表明，与周边区的RPE细胞相比，来自黄斑区的RPE细胞中酸性磷酸酶和组织蛋白酶D的活性显著更高。中区的值似乎介于其他两个区域之间。此外，两种酶的总体活性均随年龄增长而增加。