Folkerth R D
Harvard Medical School, Boston, Massachusetts.
Neurosurg Clin N Am. 1994 Jan;5(1):1-18.
The rapid diagnostic techniques of smears and frozen sections are fundamental to the strategy of the neuropathologist in evaluating tissue received at the time of operating room consultation with the neurosurgeon. This strategy begins with the exclusion of nonneoplastic lesions and proceeds to determination of the neoplastic cell type, or, in the case of reoperation of a treated tumor, the distinction of viable from necrotic tumor. In the interest of conserving unfrozen tissue for permanent sections, a smear may be made and examined initially, with a frozen section prepared only if the smear is equivocal or technically inadequate. This approach has been shown to result in a degree of diagnostic accuracy comparable to that described in general surgical material subject to frozen section analysis.
涂片和冰冻切片的快速诊断技术是神经病理学家在与神经外科医生进行手术室会诊时评估所接收组织的策略基础。该策略首先排除非肿瘤性病变，然后确定肿瘤细胞类型，或者在已治疗肿瘤再次手术的情况下，区分存活肿瘤与坏死肿瘤。为了保留未冷冻的组织用于制作永久切片，可先制作涂片并进行初步检查，仅在涂片结果不明确或技术上不充分时才制备冰冻切片。已证明这种方法所达到的诊断准确率与一般外科材料经冰冻切片分析所描述的准确率相当。
