用猪繁殖与呼吸综合征病毒（PRCV）对妊娠后备母猪进行免疫可诱导产生泌乳免疫，以保护哺乳仔猪免受传染性胃肠炎病毒（TGEV）攻击。
Immunization of pregnant gilts with PRCV induces lactogenic immunity for protection of nursing piglets from challenge with TGEV.
作者信息
Wesley R D, Woods R D
机构信息
Virology Swine Research Unit National Animal Disease Center USDA, Agricultural Research Service, Ames, IA 50010.
出版信息
Vet Microbiol. 1993 Dec;38(1-2):31-40. doi: 10.1016/0378-1135(93)90073-g.
Abstract
The level of passive protection against transmissible gastroenteritis virus (TGEV) was evaluated by experimentally infecting 12 pregnant gilts with different doses of porcine respiratory coronavirus (PRCV) and challenging their litters at 4 days of age. An overall survival rate of 70% was found for piglets nursing the 12 PRCV-infected gilts, compared to a 16% survival rate for piglets of nine uninfected control gilts. Six of the PRCV-infected gilts had adequate levels of immunity to resist infection with TGEV following the challenge of their litters. These six completely immuned gilts also solidly protected their litters from TGEV as shown by a 96% piglet survival rate through weaning at 3 weeks of age. The results suggest that respiratory infection with PRCV induces a substantial degree of protective lactogenic immunity against TGEV.
摘要
通过用不同剂量的猪呼吸道冠状病毒（PRCV）对12头怀孕母猪进行实验性感染，并在其仔猪4日龄时用传染性胃肠炎病毒（TGEV）进行攻毒，评估了对TGEV的被动保护水平。哺乳12头感染PRCV母猪的仔猪总体存活率为70%，而9头未感染对照母猪的仔猪存活率为16%。在对其仔猪进行攻毒后，6头感染PRCV的母猪具有足够的免疫力来抵抗TGEV感染。这6头完全免疫的母猪也有力地保护了它们的仔猪免受TGEV感染，3周龄断奶时仔猪存活率达96%即表明了这一点。结果表明，PRCV呼吸道感染可诱导对TGEV产生相当程度的保护性乳源性免疫。
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