Taylor-Robinson D, Thomas B J, Dixey J, Osborn M F, Furr P M, Keat A C
Division of Sexually Transmitted Diseases, MRC Clinical Research Centre, Harrow, Middlesex.
Ann Rheum Dis. 1988 Apr;47(4):295-9. doi: 10.1136/ard.47.4.295.
Chlamydia trachomatis elementary bodies (EBs) were found in synovial membranes or synovial fluid cell deposits from five of 15 women with seronegative mono- or oligoarthritis by means of a fluorescein conjugated anti-chlamydial monoclonal antibody (Micro Trak; Syva). Genital tract specimens were taken from only five of the patients, one of whom had intra-articular EBs, but none was chlamydia positive. Six of 10 patients tested were HLA-B27 positive, and chlamydial IgG antibody, measured by microimmunofluorescence, was present at a titre of 1/greater than or equal to 64 in the sera of five of the 15 patients, three of the five having EBs in their joints. In contrast, chlamydial EBs were not detected in the joints of a control group of 10 other women, most of whom had rheumatoid arthritis. None of them was HLA-B27 positive, and only one had a chlamydial antibody titre of 1/greater than or equal to 64. Neither Mycoplasma hominis nor ureaplasmas were isolated from the synovial fluids of seven patients and five controls who were tested. Antibody to M genitalium, however, was detected in five of the 10 patients but in none of the controls. This evidence apart, there was no other suggest that mycoplasmas or ureaplasmas might be responsible for arthritis which could not be attributed to chlamydiae.
通过荧光素偶联抗衣原体单克隆抗体（Micro Trak；Syva公司），在15例血清阴性单关节炎或寡关节炎女性患者中的5例患者的滑膜或滑膜液细胞沉积物中发现了沙眼衣原体原体（EBs）。仅对其中5例患者采集了生殖道标本，其中1例患者关节内有EBs，但均未检测出衣原体阳性。10例接受检测的患者中有6例HLA - B27阳性，通过微量免疫荧光法检测，15例患者中有5例血清中衣原体IgG抗体滴度为1/≥64，5例中有3例关节中有EBs。相比之下，在另外10名女性对照组患者的关节中未检测到衣原体EBs，这些女性大多患有类风湿关节炎。她们中没有HLA - B27阳性的，只有1例衣原体抗体滴度为1/≥64。在7例患者和5例接受检测的对照者的滑膜液中均未分离出人型支原体和脲原体。然而，10例患者中有5例检测到生殖支原体抗体，而对照者中均未检测到。除此之外，没有其他证据表明支原体或脲原体可能是无法归因于衣原体的关节炎的病因。
