Mårdh P A, Colleen S
Scand J Urol Nephrol. 1975;9(1):17-23. doi: 10.3109/00365597509139907.
The antibacterial, antifungal and antimycoplasmal activity of human semen was studied. Gram-positive aerobic bacterial species i.e. staphylococci, but not gram-negative aerobic bacteria, were inhibited by seminal fluid in vitro. Neither were anaerobic gram-positive or gram-negative bacteria, nor Candida or Mycoplasma inhibited. Semen of healthy males had a higher antibacterial effect on S. albus than that of patients with symptoms of chronic prostatitis. There was a positive correlation between the antibacterial power of the semen of the patients studied and their content of zinc and magnesium, while no correlation was found with fructose and lysozyme or the number of spermatozoa in any of the groups. A positive correlation was found between the antibacterial capacity and the volume of the ejaculate in the patients but not among the controls. The antibacterial substance(s) was dialysable, ether-extractable, resistant to boiling and partly to storage at room temperature. The addition of EDTA, tranexamic acid and ammonium reineckate to semen did not influence the antibacterial effect, which was, however, slightly inhibited by sodium polyanethol sulphonate. The nature of possible antibacterial substances in semen is discussed.
对人类精液的抗菌、抗真菌和抗支原体活性进行了研究。在体外，精液可抑制革兰氏阳性需氧菌（即葡萄球菌），但不能抑制革兰氏阴性需氧菌。厌氧革兰氏阳性菌或革兰氏阴性菌、念珠菌或支原体均未受到抑制。健康男性的精液对白色念珠菌的抗菌作用高于患有慢性前列腺炎症状的患者。在所研究患者精液的抗菌能力与其锌和镁含量之间存在正相关，而在任何组中均未发现与果糖、溶菌酶或精子数量存在相关性。在患者中发现抗菌能力与射精量之间存在正相关，但在对照组中未发现。抗菌物质是可透析的、可乙醚萃取的、耐煮沸的，并且在室温下部分耐储存。向精液中添加乙二胺四乙酸、氨甲环酸和雷氏铵盐不影响抗菌效果，然而，多聚茴香脑磺酸钠会轻微抑制该效果。文中讨论了精液中可能的抗菌物质的性质。
