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组织培养细胞对促进淋病奈瑟菌在小鼠人工皮下腔中长期存活的影响。

Effect of tissue culture cells in promoting prolonged survival of N. Gonorrhoeae in artificial subcutaneous cavities of mice.

作者信息

Waitkins S A

出版信息

Br J Vener Dis. 1975 Dec;51(6):376-81. doi: 10.1136/sti.51.6.376.

DOI:10.1136/sti.51.6.376
PMID:814964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1045185/
Abstract

Both tissue culture cells and human epithelial cells ingest gonococci, and subsequently protect them from the lethal action of various bactericidal agents. Using the convenient chamber produced by the subcutaneous insertion of a polyvinyl ring, the fate of the gonococci in mice was studied in vivo. Both humoral and cellular factors have free access to the organisms, and under normal circumstances these do not survive longer than 3 days. However, when gonococci were protected within tissue culture cells, their survival was prolonged. Only eventual graft rejection caused the death of the tissue culture cells and gonococci contained within them.

摘要

组织培养细胞和人类上皮细胞均可摄取淋球菌，并随后保护它们免受各种杀菌剂的致死作用。利用通过皮下插入聚乙烯环所产生的便利腔室，在体内研究了淋球菌在小鼠体内的命运。体液和细胞因子均可自由接触这些微生物，在正常情况下，它们存活时间不超过3天。然而，当淋球菌在组织培养细胞内得到保护时，它们的存活时间会延长。只有最终的移植物排斥才会导致组织培养细胞及其内所含淋球菌的死亡。

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Effect of tissue culture cells in promoting prolonged survival of N. Gonorrhoeae in artificial subcutaneous cavities of mice.组织培养细胞对促进淋病奈瑟菌在小鼠人工皮下腔中长期存活的影响。
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本文引用的文献

1
Nutrition of animal cells in tissue culture; initial studies on a synthetic medium.组织培养中动物细胞的营养；对合成培养基的初步研究。
Proc Soc Exp Biol Med. 1950 Jan;73(1):1-8. doi: 10.3181/00379727-73-17557.
2
NEISSERIA GONORRHOEAE IDENTIFICATION IN DIRECT SMEARS BY A FLUORESCENT ANTIBODY-COUNTERSTAIN METHOD.采用荧光抗体复染法对直接涂片进行淋病奈瑟菌鉴定。
Appl Microbiol. 1965 Mar;13(2):171-4. doi: 10.1128/am.13.2.171-174.1965.
3
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
4
Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
5
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
6
Neisseria gonorrhoeae: experimental infection of laboratory animals.淋病奈瑟菌：实验动物的感染实验
Science. 1972 Sep 29;177(4055):1200-1. doi: 10.1126/science.177.4055.1200.
7
A serum-free medium for testing fermentation reactions in Neisseria gonorrhoeae.一种用于检测淋病奈瑟菌发酵反应的无血清培养基。
J Clin Pathol. 1972 Jun;25(6):525-7. doi: 10.1136/jcp.25.6.525.
8
Intracellular growth and type variation of Neisseria gonorrhoeae in tissue cell-cultures.
J Med Microbiol. 1973 Aug;6(3):399-403. doi: 10.1099/00222615-6-3-399.