Welter C, Seitz G, Blin N
Institut für Humangenetik, Universität des Saarlandes, Homburg/Saar, Germany.
Acta Oncol. 1993;32(3):315-7. doi: 10.3109/02841869309093602.
The breast cancer-associated protein pS2 is also present in many human gastrointestinal tumors. In contrast to breast carcinomas, gastrointestinal tumors do not express estrogen receptors, indicating that the expression of pS2 is not estrogen-dependent. The pS2 expression was analyzed in 14 adenosquamous tumors of the human gastrointestinal tract. The aim was to investigate if the cell type specific localization of pS2 was limited to the glandular part. The data clearly confirm such a specific compartmentation of the pS2 expression, suggesting pS2 to be a secreted protein. Due to the specific expression, pS2 may become a new and useful diagnostic marker of adenocarcinoma.
乳腺癌相关蛋白pS2也存在于许多人类胃肠道肿瘤中。与乳腺癌不同，胃肠道肿瘤不表达雌激素受体，这表明pS2的表达不依赖于雌激素。对14例人类胃肠道腺鳞癌肿瘤中的pS2表达进行了分析。目的是研究pS2的细胞类型特异性定位是否仅限于腺性部分。数据清楚地证实了pS2表达的这种特异性分隔，提示pS2是一种分泌蛋白。由于其特异性表达，pS2可能成为腺癌一种新的有用的诊断标志物。
