Brune D, Aitio A, Nordberg G, Vesteberg O, Gerhardsson L
Dag Brune Consulting, Oslo, Norway.
Scand J Work Environ Health. 1993;19 Suppl 1:39-44.
The validity of "normal" concentrations for total chromium in serum and urine (S-Cr and U-Cr, respectively) in papers published mainly in the last decade were evaluated and graded by two investigators according to TRACY criteria. The results were in close agreement. Because of possible contamination during sampling from stainless steel needles, the description of the sample collection method was considered important. Documentation of analytical quality control was emphasized. The chromium concentrations were categorized according to nonoccupational conditions that could influence the levels. Eighty-seven publications reporting chromium concentrations in blood and 58 on U-Cr were evaluated, 53 dealing with S-Cr and 41 with U-Cr being found suitable for the TRACY project. In selected publications the arithmetic mean values presented for S-Cr and U-Cr in individuals with no known exposure were within the following ranges: 1-3 nmol.1-1 for S-Cr and 2-10 nmol.1-1 or 0.2-1 mumol.mol creatinine-1 for U-Cr.
两位研究人员根据TRACY标准，对主要在过去十年发表的论文中血清和尿液中总铬（分别为S-Cr和U-Cr）“正常”浓度的有效性进行了评估和分级。结果高度一致。由于使用不锈钢针采样时可能存在污染，样本采集方法的描述被认为很重要。强调了分析质量控制的记录。根据可能影响铬浓度水平的非职业条件对铬浓度进行了分类。对87篇报告血液中铬浓度的出版物和58篇关于U-Cr的出版物进行了评估，发现53篇关于S-Cr和41篇关于U-Cr的出版物适合TRACY项目。在选定的出版物中，无已知暴露个体的S-Cr和U-Cr算术平均值在以下范围内：S-Cr为1-3 nmol·L-1，U-Cr为2-10 nmol·L-1或0.2-1 μmol·mol肌酐-1。
