Maggi E, Finardi G, Poli M, Bollati P, Filipponi M, Stefano P L, Paolini G, Grossi A, Clot P, Albano E
Department of Internal Medicine and Medical Therapeutics, University of Pavia, Italy.
Coron Artery Dis. 1993 Dec;4(12):1119-22. doi: 10.1097/00019501-199312000-00014.
LDL oxidation is a crucial step in the development and progression of atherosclerotic lesions. The detection of an increase in the anti-oxidized LDL antibody titre may thus represent a biological marker of enhanced LDL oxidation in vivo.
The occurrence of anti-oxidized LDL autoantibodies was investigated in control patients, in patients with atherosclerotic coronary artery disease, in those without clinically relevant signs of atherosclerosis, but considered at risk, and in patients with chronic alcohol-related liver disease.
Anti-oxidized LDL autoantibodies were present in the plasma of the majority of patients with overt coronary atherosclerosis. An increased antibody titre can also be detected well before the onset of clinically relevant signs of the atherosclerotic disease in patients classically considered at risk, indicating the occurrence of in-vivo LDL oxidation during atherosclerosis development. The specificity of molecular targets (LDL) for oxidative modifications is supported by the demonstration that anti-oxidized LDL autoantibodies are absent in the plasma of alcoholic patients who exhibit a marked increase in biological markers of oxidative stress but do not classically develop atherosclerosis.
These data demonstrate that the occurrence of anti-oxidized LDL autoantibodies could be specifically related to the promotion and progression of atherosclerosis and is not a simple epiphenomenon of any oxidative process occurring in vivo.
低密度脂蛋白（LDL）氧化是动脉粥样硬化病变发生和发展的关键步骤。因此，检测抗氧化LDL抗体滴度的升高可能代表体内LDL氧化增强的生物学标志物。
在对照患者、动脉粥样硬化性冠状动脉疾病患者、无动脉粥样硬化临床相关体征但被认为有风险的患者以及慢性酒精性肝病患者中研究抗氧化LDL自身抗体的发生情况。
大多数明显冠状动脉粥样硬化患者的血浆中存在抗氧化LDL自身抗体。在经典的有风险患者中，在动脉粥样硬化疾病临床相关体征出现之前也能检测到抗体滴度升高，这表明在动脉粥样硬化发展过程中发生了体内LDL氧化。氧化应激生物学标志物显著升高但通常不发生动脉粥样硬化的酒精性患者血浆中不存在抗氧化LDL自身抗体，这证明了氧化修饰的分子靶点（LDL）的特异性。
这些数据表明，抗氧化LDL自身抗体的出现可能与动脉粥样硬化的进展和发展有特定关系，而不是体内发生的任何氧化过程的简单附带现象。
