麻风杆菌的初步分类学研究。
Preliminary taxonomic studies on the leprosy bacillus.
作者信息
Stanford J L, Rook G A, Convit J, Godal T, Kronvall G, Rees R J, Walsh G P
出版信息
Br J Exp Pathol. 1975 Dec;56(6):579-85.
Antigens extracted from leprosy bacilli obtained from infected human and armadillo tissues have been examined by immunodiffusion analysis with serum samples from lepromatous patients and with immune sera raised in rabbits. Using the best combinations of serum and antigen extracts, 12 antigenic constituents were found in the leprosy bacilli. Six of these were antigens common to all mycobacteria and nocardiae, 4 were specific to the leprosy bacillus and the position of 2 could not be determined. Groups ii and iii antigens (i.e. those associated with the slow growing and fast growing subgenera of mycobacteria) were not found in theleprosy bacillus, suggesting some relationship with M. vaccae and similar strains, in which these antigens are also missing. Lymphocyte transformation tests performed on lymph node cells of mice infected or immunized with leprosy bacilli also showed the leprosy bacillus to have a closer relationship with M. vaccae than with other mycobacteria.
已采用来自瘤型麻风病人的血清样本以及在兔子体内产生的免疫血清，通过免疫扩散分析检测了从感染人类和犰狳组织中获取的麻风杆菌提取的抗原。利用血清和抗原提取物的最佳组合，在麻风杆菌中发现了12种抗原成分。其中6种是所有分枝杆菌和诺卡氏菌共有的抗原，4种是麻风杆菌特有的，另外2种的位置无法确定。在麻风杆菌中未发现第二组和第三组抗原（即那些与分枝杆菌生长缓慢和快速生长的亚属相关的抗原），这表明其与母牛分枝杆菌及类似菌株存在某种关系，在这些菌株中这些抗原也缺失。对感染或用麻风杆菌免疫的小鼠淋巴结细胞进行的淋巴细胞转化试验也表明，麻风杆菌与母牛分枝杆菌的关系比与其他分枝杆菌更为密切。
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