Ihara T, Oitani K, Torigoe S, Kitamura K, Ito M, Kamiya H, Sakurai M
Department of Pediatrics, Mie National Hospital, Japan.
Acta Paediatr Jpn. 1994 Feb;36(1):53-6. doi: 10.1111/j.1442-200x.1994.tb03129.x.
To eliminate the role of natural killer (NK), antibody-dependent cell-mediated cytotoxicity (ADCC), and polymorphonuclear leukocyte (PMN)-mediated cytotoxicity in Varicella zoster virus (VZV) infections, peripheral blood mononuclear cell (PBMC)-mediated NK and ADCC, and phorbol myristate acetate-stimulated PMN-mediated cytotoxicity against VZV-infected targets were studied in children with leukemia. Natural killer and PMN-mediated cytotoxic activity was depressed for 6 months after complete remission and ADCC activity was depressed for 1 year after complete remission. The magnitude of three cytotoxic mechanisms in leukemic children gradually increased while they continued in complete remission. These results suggested that decreased cytotoxic activities of PBMC and PMN might contribute to serious VZV infections and susceptibility to herpes zoster in leukemic children.
为消除自然杀伤细胞（NK）、抗体依赖性细胞介导的细胞毒性（ADCC）和多形核白细胞（PMN）介导的细胞毒性在水痘带状疱疹病毒（VZV）感染中的作用，对白血病患儿外周血单核细胞（PBMC）介导的NK和ADCC以及佛波醇肉豆蔻酸酯乙酸酯刺激的PMN对VZV感染靶标的细胞毒性进行了研究。完全缓解后6个月，自然杀伤细胞和PMN介导的细胞毒性活性降低，完全缓解后1年，ADCC活性降低。白血病患儿在持续完全缓解期间，三种细胞毒性机制的强度逐渐增加。这些结果表明，PBMC和PMN的细胞毒性活性降低可能导致白血病患儿发生严重的VZV感染和对带状疱疹易感。
