Yasugi T, Kawai T, Mizunuma K, Kishi R, Harabuchi I, Yuasa J, Eguchi T, Sugimoto R, Seiji K, Ikeda M
Chugoku-Shikoku Occupational Health Service Center, Hiroshima, Japan.
Int Arch Occup Environ Health. 1994;65(5):343-50. doi: 10.1007/BF00405700.
A survey was conducted in the second half of a working week on 33 women who either applied glue (with cyclohexane as an almost exclusive solvent component) or worked in the vicinity of glue application. Carbon cloth-equipped diffusive samplers were used for personal measurement of time-weighted average intensity of exposure to the solvent. The geometric mean and the highest cyclohexane concentration observed in air were 27 ppm and 274 ppm, respectively. Concentrations of cyclohexanol in urine samples and cyclohexane in whole blood and serum collected at the end of a shift showed significant correlations with the solvent exposure levels. Urinary cyclohexanone also correlated, but with a smaller correlation coefficient. The observation suggests that cyclohexanol in urine and cyclohexane in blood or serum collected at the end of a shift are useful indicators of occupational exposure to cyclohexane vapor. Quantitative estimation of balance at the end of the shift suggested that only a minute portion (< 1%) of cyclohexane absorbed is excreted in the urine as cyclohexanol, almost exclusively as a glucuronide. A survey of subjective symptoms revealed an increase in the prevalence of "dimmed vision " and "unusual smell", but hematology and serum biochemistry testing did not indicate any specific signs.
在一个工作周的后半段，对33名女性进行了一项调查，这些女性要么使用胶水（环己烷几乎是唯一的溶剂成分），要么在胶水使用区域附近工作。配备碳布的扩散采样器用于个人测量溶剂暴露的时间加权平均强度。空气中观察到的环己烷几何平均浓度和最高浓度分别为27 ppm和274 ppm。轮班结束时采集的尿液样本中环己醇浓度、全血和血清中环己烷浓度与溶剂暴露水平呈显著相关。尿中环己酮也存在相关性，但相关系数较小。该观察结果表明，轮班结束时采集的尿液中环己醇以及血液或血清中环己烷是职业性接触环己烷蒸气的有用指标。轮班结束时的平衡定量估计表明，吸收的环己烷中只有极小一部分（<1%）以环己醇形式经尿液排出，几乎完全以葡萄糖醛酸苷形式排出。主观症状调查显示，“视力模糊”和“异味”的患病率有所增加，但血液学和血清生化检测未显示任何特定体征。
