Milot E, Belmaaza A, Rassart E, Chartrand P
Canadian Red Cross Society, Research and Development, Montreal Centre, Québec.
Virology. 1994 Jun;201(2):408-12. doi: 10.1006/viro.1994.1310.
Integration of retroviral genomes is a site-specific process with respect to the virus but not the host genome. Numerous chromosomal sites and various sequences can be used as targets. Nevertheless, preferential regions and integration patterns have been observed. Using a functional assay, we investigated if host structural DNA elements could be associated with retroviral integration sites. The results were that 9 of 10 distinct retroviral integration events occurred in close proximity of structural elements behaving like intrinsically bent DNA.
逆转录病毒基因组的整合对于病毒而言是一个位点特异性过程，但对于宿主基因组则不然。许多染色体位点和各种序列都可作为靶点。然而，已观察到存在优先区域和整合模式。我们使用功能测定法研究宿主结构DNA元件是否可能与逆转录病毒整合位点相关联。结果是，10个不同的逆转录病毒整合事件中有9个发生在表现出类似固有弯曲DNA的结构元件附近。
