人类免疫缺陷病毒1型整合位点侧翼的人类DNA序列分析。
Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration.
作者信息
Stevens S W, Griffith J D
机构信息
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill 27599-7295, USA.
出版信息
J Virol. 1996 Sep;70(9):6459-62. doi: 10.1128/JVI.70.9.6459-6462.1996.
Abstract
Human immunodeficiency virus type 1 (HIV-1) tagged with the Escherichia coli supF gene has been used to clone integrated HIV-1 proviruses. Sequence analysis of the 600 to 800 bp of human DNA adjacent to 29 clones revealed a propensity for HIV-1 to integrate near the Alu class of human repetitive elements.
摘要
携带大肠杆菌supF基因的1型人类免疫缺陷病毒（HIV-1）已被用于克隆整合的HIV-1前病毒。对与29个克隆相邻的600至800碱基对人类DNA进行的序列分析显示，HIV-1倾向于整合在人类重复元件的Alu类附近。
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