Eagle C J, Maltby J R, Kryski S, Hardy D
Department of Anaesthesia, Foothills Hospital, University of Calgary, Alberta.
Can J Anaesth. 1994 Mar;41(3):248-52. doi: 10.1007/BF03009840.
The purpose of this laboratory study was to assess the value of refractometry in identifying the contents of a variety of opioid-containing solutions. A hand-held refractometer was used to document the refraction produced by the undiluted contents of alfentanil, fentanyl, morphine, sufentanil ampoules and by solutions of Ringer's lactate, 0.9% saline, 3.3% dextrose in 0.3% saline, and distilled water. Each opioid was then serially diluted in serial 1:2, 1:4, and 1:8 dilutions in each of these solutions and the refractions of each determined. Based on this information, blinded identification of various diluted opioid solutions was attempted. Refractometer values for undiluted fentanyl and sufentanil were identical with those for distilled water. Those for undiluted alfentanil and morphine were almost identical with each other and with 1:2 and 1:4 dilutions of either drug in Ringer's lactate or 0.9% saline. We conclude that refractometry is an unreliable screening method to detect tampering with opioid solutions.
本实验室研究的目的是评估折射测定法在识别多种含阿片类药物溶液成分方面的价值。使用手持折射仪记录阿芬太尼、芬太尼、吗啡、舒芬太尼安瓿原液以及乳酸林格氏液、0.9%生理盐水、0.3%生理盐水中3.3%葡萄糖溶液和蒸馏水所产生的折射。然后将每种阿片类药物在上述每种溶液中按1:2、1:4和1:8的比例进行连续稀释，并测定每种稀释液的折射。基于这些信息，尝试对各种稀释的阿片类药物溶液进行盲法识别。未稀释的芬太尼和舒芬太尼的折射仪值与蒸馏水的相同。未稀释的阿芬太尼和吗啡的折射仪值彼此几乎相同，且与这两种药物在乳酸林格氏液或0.9%生理盐水中1:2和1:4稀释液的折射仪值几乎相同。我们得出结论，折射测定法是一种不可靠的检测阿片类药物溶液是否被篡改的筛查方法。
