Bouchon R, Ropartz P
Laboratoire de Psychophysiologie, URA CNRS 1295, Université Louis Pasteur, Strasbourg, France.
Physiol Behav. 1994 Apr;55(4):711-5. doi: 10.1016/0031-9384(94)90049-3.
The effects of ectopic pituitary grafts, sex of pituitary donor, and number of isografts (one or two) were examined in intact phenotypically normal male mice of the Snell dwarf strain, using a battery of tests designed to assess exploration and learning-related behavioral processes. Results show that neither sex of pituitary donor nor number of grafts affected behavioral responses to pituitary grafts. Ectopic pituitary grafts increased the level of exploratory activities assessed in a novelty preference test and in the hole board test, facilitated the retention of a step-through type passive avoidance task--contrasting with results in rats--but did not affect spatial orientation in a spontaneous alternation and a water escape task. The results argue for a global effect of the graft, inducing increased emotional reactivity.
在表型正常的斯内尔侏儒品系雄性小鼠中，使用一系列旨在评估探索和学习相关行为过程的测试，研究了异位垂体移植的影响、垂体供体的性别以及同基因移植的数量（一个或两个）。结果表明，垂体供体的性别和移植数量均未影响对垂体移植的行为反应。异位垂体移植增加了在新奇偏好测试和孔板测试中评估的探索活动水平，促进了一步通过型被动回避任务的记忆保持——这与在大鼠中的结果形成对比——但在自发交替和水迷宫逃避任务中不影响空间定向。这些结果表明移植具有整体效应，可诱导情绪反应性增加。
