Norris R M, Clarke E D, Sammel N L, Smith W M, Williams B
Lancet. 1978 Oct 28;2(8096):907-9. doi: 10.1016/s0140-6736(78)91628-8.
Propranolol 0.1 mg/kg intravenously followed by 320 mg orally over 27 h was given to 20 randomly selected patients within 4 h of the onset of suspected myocardial infarction unaccompanied by diagnostic electrocardiographic changes. Patients given propranolol had fewer completed infarcts as assessed by serial electrocardiograms, a lower frequency of serum-creatine-kinase levels above the normal range, and lower peak serum-creatine-kinase levels than 23 control subjects. This evidence suggests that threatened myocardial infarction can in some cases be prevented by early beta-adrenoceptor blockade.
在疑似心肌梗死发作后4小时内，对20例随机选择的患者静脉注射0.1mg/kg普萘洛尔，随后在27小时内口服320mg，这些患者未伴有诊断性心电图改变。通过系列心电图评估，接受普萘洛尔治疗的患者梗死灶形成较少，血清肌酸激酶水平高于正常范围的频率较低，且血清肌酸激酶峰值水平低于23例对照受试者。这一证据表明，在某些情况下，早期β-肾上腺素能受体阻滞剂可预防心肌梗死的发生。
