大鼠脑脊液系统动力学的测量

Measurement of the dynamics of the cerebrospinal fluid system in the rat.

作者信息

Bötel C, Brinker T

机构信息

Department of Central Laboratory Animal Facility, Medical School, Hannover, Germany.

出版信息

J Exp Anim Sci. 1994 Mar;36(2-3):78-83.

PMID:8193175

Abstract

A technique for intracranial pressure (ICP) monitoring in the rat that enables the measurement of the cerebrospinal outflow resistance (RCSF) and the intracranial pressure-volume index (PVI) is described. A permanent catheter placed into the cisterna magna through the occipital bone was used. ICP, RCF and PVI were measured in ten LEW rats. The baseline ICP was 8 +/- 1.7 mm Hg (Mean +/- S.D.). The PVI was 0.0518 +/- 0.018 ml. The RCSF was 464 +/- 196 mm Hg ml-1 min-1 which is less than reported previously. The cannulation technique easy and gives reliable pressure tracings. It enables ICP monitoring and estimation of the dynamics of the cerebrospinal fluid (CSF) system during experimental surgical procedures in the rat.

摘要

本文描述了一种用于大鼠颅内压（ICP）监测的技术，该技术能够测量脑脊液流出阻力（RCSF）和颅内压力-容积指数（PVI）。使用一根通过枕骨置入大池的永久性导管。对10只LEW大鼠进行了ICP、RCF和PVI的测量。基线ICP为8±1.7 mmHg（平均值±标准差）。PVI为0.0518±0.018 ml。RCSF为464±196 mmHg ml-1 min-1，低于先前报道的值。插管技术简便，能给出可靠的压力描记图。它能够在大鼠实验性外科手术过程中进行ICP监测并评估脑脊液（CSF）系统的动力学。