与微球菌素P相关的三种新型抗生素硫霉素I、II和III的分离。芽孢杆菌属抗生素研究。VIII。

Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P. Studies on antibiotics from the genus Bacillus. VIII.

作者信息

Shoji J, Hinoo H, Wakisaka Y, Koizumi K, Mayama M

出版信息

J Antibiot (Tokyo). 1976 Apr;29(4):366-74. doi: 10.7164/antibiotics.29.366.

DOI:10.7164/antibiotics.29.366

PMID:819410

Abstract

Thiocillins I and II were isolated from the culture broth of Bacillus cereus G-15, and thiocillins II and III from that of Bacillus badius AR-91. Also, the former two were probably produced by Bacillus megatherium I-13. These antibiotics active against Gram-positive bacteria are soluble in a mixture of chloroform and methanol, show characteristic ultraviolet absorptions (maxima at ca. 275 nm and ca. 348 nm), and contain a high content of sulfur, as much as approximately 15%. They are related to each other and also to micrococcin P, but differentiated by chromatographic behaviours.

摘要

硫霉素I和II是从蜡样芽孢杆菌G-15的培养液中分离得到的，硫霉素II和III则是从短芽孢杆菌AR-91的培养液中分离得到的。此外，前两者可能是由巨大芽孢杆菌I-13产生的。这些对革兰氏阳性菌有活性的抗生素可溶于氯仿和甲醇的混合液中，呈现出特征性的紫外吸收（在约275nm和约348nm处有最大值），并且含有高达约15%的硫。它们彼此相关，也与微球菌素P相关，但通过色谱行为得以区分。