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第二出生的双胞胎:我们能改善其结局吗?

The second-born twin: can we improve outcomes?

作者信息

Prins R P

机构信息

Department of Obstetrics and Gynecology, Manuel Hospital, Portland, OR.

出版信息

Am J Obstet Gynecol. 1994 Jun;170(6):1649-56; discussion 1656-7.

PMID:8203422
Abstract

OBJECTIVE

Second-born twin outcome was compared with that of the first-twin birth mate to determine whether there were differences, the reason for the differences, if any, and the clinical decisions that could be made to eliminate or ameliorate these differences.

STUDY DESIGN

Twin pregnancies from 1989 through 1992 were retrospectively reviewed. Charts demonstrating both twins stillborn, either twin weighing < 500 gm, or either twin with a serious congenital anomaly were excluded from evaluation. After these exclusions 200 twin pairs remained for analysis. Each twin was compared directly with its birth mate. The first twin is postulated as having the best possible outcome for the pregnancy involved, and second-twin outcomes are compared with these.

RESULTS

The second-born twin was more likely to be intubated, have respiratory distress syndrome, need resuscitation, and have lower 5-minute Apgar scores. Second-born twins had more nursery complications. The < 1500 gm group appeared to be at special risk. In this group there were more second-born twin neonatal deaths and much higher rates of intubation and resuscitation. Nonvertex presentation in the second-born twin increased chances for resuscitation, intubation, respiratory distress syndrome, and nursery complications. These outcomes in the second-born were not affected by cesarean delivery.

CONCLUSIONS

The second-born twin is at increased risk of untoward outcome compared with its birth mate. Some of this risk can be attributed to birth weight. The risk posed by nonvertex presentation is small. Cesarean section delivery does not appear to eliminate the difference between first- and second-twin outcome. Prospective studies are needed.

摘要

目的

比较第二出生的双胞胎与第一出生的双胞胎的结局,以确定是否存在差异、差异的原因(如有)以及可以做出哪些临床决策来消除或改善这些差异。

研究设计

回顾性分析了1989年至1992年的双胎妊娠。排除显示双胞胎均为死产、任一胎儿体重<500克或任一胎儿有严重先天性异常的病历后进行评估。排除这些病例后,剩余200对双胞胎进行分析。每对双胞胎都与其出生的同胞直接进行比较。假定第一出生的双胞胎对所涉及的妊娠有最好的结局,并将第二出生的双胞胎的结局与之进行比较。

结果

第二出生的双胞胎更有可能需要插管、患呼吸窘迫综合征、需要复苏且5分钟阿氏评分较低。第二出生的双胞胎有更多的新生儿并发症。体重<1500克的组似乎有特殊风险。在该组中,第二出生的双胞胎新生儿死亡更多,插管和复苏率更高。第二出生的双胞胎非头位分娩增加了复苏、插管、呼吸窘迫综合征和新生儿并发症的几率。第二出生的双胞胎的这些结局不受剖宫产的影响。

结论

与第一出生的双胞胎相比,第二出生的双胞胎出现不良结局的风险增加。部分风险可归因于出生体重。非头位分娩带来的风险较小。剖宫产似乎并不能消除第一和第二出生的双胞胎结局之间的差异。需要进行前瞻性研究。

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