修饰聚肌苷酸-聚胞苷酸，一种免疫佐剂。
Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant.
作者信息
Houston W E, Crabbs C L, Stephen E L, Levy H B
出版信息
Infect Immun. 1976 Jul;14(1):318-9. doi: 10.1128/iai.14.1.318-319.1976.
Abstract
Stabilization of polyriboinosinic-polyribocytidylic acid against enzymatic hydrolysis by addition of poly-1-lysine and carboxymethylcellulose (PICLC) resulted in a compound with marked adjuvanticity. The primary antibody response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if the vaccine was combined with PICLC prior to vaccination. The antibody response was maintained at a significantly higher level than controls for 2.5 months postvaccination and paralleled immunological responses reported for live, attenuated (TC-83) vaccine.
摘要
通过添加聚-L-赖氨酸和羧甲基纤维素（PICLC）使聚肌苷酸-聚胞苷酸对酶促水解稳定，从而得到一种具有显著佐剂活性的化合物。如果在接种前将福尔马林灭活的委内瑞拉马脑炎病毒疫苗与PICLC联合使用，恒河猴对该疫苗的初次抗体反应会显著增强。接种疫苗后2.5个月，抗体反应维持在显著高于对照组的水平，且与减毒活疫苗（TC-83）报道的免疫反应相似。
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