• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乙型流感病毒分离株血凝素对唾液酸糖链介导识别的特异性

Specificity of sialyl-sugar chain mediated recognition by the hemagglutinin of human influenza B virus isolates.

作者信息

Xu G, Suzuki T, Tahara H, Kiso M, Hasegawa A, Suzuki Y

机构信息

Department of Biochemistry, University of Shizuoka School of Pharmaceutical Science.

出版信息

J Biochem. 1994 Feb;115(2):202-7. doi: 10.1093/oxfordjournals.jbchem.a124318.

DOI:10.1093/oxfordjournals.jbchem.a124318
PMID:8206868
Abstract

Recognition specificity for sialylsugar chains by the hemagglutinin of influenza B viruses isolated in different years from 1940 through 1990 (B/Lee/40, B/Setagaya/3/56, B/Tokyo/7/66, B/Kagoshima/1/68, B/Gifu/2/73, B/Kanagawa/3/76, B/Ibaraki/2/85, B/Yamagata/16/88, and B/Bangkok/163/90) was studied using 13 gangliosides. Reactivity of the viruses' hemagglutinin binding to gangliosides was determined by using thin-layer chromatography/virus-binding assay, and also by measuring virus binding to erythrocytes modified by incubation with gangliosides in terms of the absorbance of hemoglobin released from the infected cells. Eight strains preferentially recognized a novel ganglioside, carrying lacto-series type I and II sugar chains with the Neu5Ac alpha 2-6Gal linkage. It was found that B/Gifu/2/73 strain binds to lacto-series gangliosides containing Neu5Ac alpha 2-6Gal and Neu5Ac alpha 2-3Gal linkages. Other gangliosides studied, including GM4, GM3(alpha 2-3), GM3(alpha 2-6), GM2, GM1a, GD3, GD1a, GD1b, and GT1b, were poor receptors.

摘要

利用13种神经节苷脂研究了1940年至1990年不同年份分离出的乙型流感病毒（B/Lee/40、B/Setagaya/3/56、B/Tokyo/7/66、B/Kagoshima/1/68、B/Gifu/2/73、B/Kanagawa/3/76、B/Ibaraki/2/85、B/Yamagata/16/88和B/Bangkok/163/90）血凝素对唾液酸糖链的识别特异性。通过薄层层析/病毒结合试验，以及通过测量病毒与经神经节苷脂孵育修饰的红细胞的结合情况（根据感染细胞释放的血红蛋白的吸光度）来确定病毒血凝素与神经节苷脂的反应性。8个毒株优先识别一种新型神经节苷脂，其携带具有Neu5Acα2-6Gal连接的I型和II型乳糖系列糖链。发现B/Gifu/2/73毒株与含有Neu5Acα2-6Gal和Neu5Acα2-3Gal连接的乳糖系列神经节苷脂结合。所研究的其他神经节苷脂，包括GM4、GM3（α2-3）、GM3（α2-6）、GM2、GM1a、GD3、GD1a、GD1b和GT1b，都是较差的受体。

相似文献

1
Specificity of sialyl-sugar chain mediated recognition by the hemagglutinin of human influenza B virus isolates.乙型流感病毒分离株血凝素对唾液酸糖链介导识别的特异性
J Biochem. 1994 Feb;115(2):202-7. doi: 10.1093/oxfordjournals.jbchem.a124318.
2
Drift of the sialyl-linkage specific recognition of the sialidase of influenza B virus isolates.乙型流感病毒分离株唾液酸酶对唾液酸连接的特异性识别漂移
J Biochem. 1993 Mar;113(3):304-7. doi: 10.1093/oxfordjournals.jbchem.a124043.
3
A novel strain, B/Gifu/2/73, differs from other influenza B viruses in the receptor binding specificities toward sialo-sugar chain linkage.一种新型毒株B/Gifu/2/73，在对唾液酸糖链连接的受体结合特异性方面与其他B型流感病毒不同。
Biochem Biophys Res Commun. 1996 Jul 25;224(3):815-8. doi: 10.1006/bbrc.1996.1105.
4
Structural determination of gangliosides that bind to influenza A, B, and C viruses by an improved binding assay: strain-specific receptor epitopes in sialo-sugar chains.通过改进的结合试验确定与甲型、乙型和丙型流感病毒结合的神经节苷脂的结构：唾液酸糖链中的菌株特异性受体表位
Virology. 1992 Jul;189(1):121-31. doi: 10.1016/0042-6822(92)90687-k.
5
Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. Specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached.人类甲型流感病毒血凝素将膜相关神经节苷脂中的唾液酸寡糖识别为其受体，该受体介导病毒感染的吸附和融合过程。对寡糖和唾液酸的特异性以及唾液酸所连接的序列。
J Biol Chem. 1986 Dec 25;261(36):17057-61.
6
The hemagglutinins of the human influenza viruses A and B recognize different receptor microdomains.甲型和乙型人类流感病毒的血凝素识别不同的受体微结构域。
Biochim Biophys Acta. 1987 Oct 16;903(3):417-24. doi: 10.1016/0005-2736(87)90048-4.
7
Sialidase of swine influenza A viruses: variation of the recognition specificities for sialyl linkages and for the molecular species of sialic acid with the year of isolation.甲型猪流感病毒的唾液酸酶：唾液酸连接以及唾液酸分子种类识别特异性随分离年份的变化。
Glycoconj J. 1995 Apr;12(2):156-61. doi: 10.1007/BF00731360.
8
Gangliosides as paramyxovirus receptor. Structural requirement of sialo-oligosaccharides in receptors for hemagglutinating virus of Japan (Sendai virus) and Newcastle disease virus.神经节苷脂作为副粘病毒受体。日本血凝病毒（仙台病毒）和新城疫病毒受体中唾液酸寡糖的结构要求。
J Biochem. 1985 Apr;97(4):1189-99. doi: 10.1093/oxfordjournals.jbchem.a135164.
9
A comparative assessment of TLC overlay technique and microwell adsorption assay in the examination of influenza A and Sendai virus specificities towards oligosaccharides and sialic acid linkages of gangliosides.薄层色谱覆盖技术和微孔吸附测定法在检测甲型流感病毒和仙台病毒对神经节苷脂的寡糖及唾液酸连接特异性方面的比较评估。
Glycoconj J. 1994 Oct;11(5):486-92. doi: 10.1007/BF00731285.
10
Specificity of the N1 and N2 sialidase subtypes of human influenza A virus for natural and synthetic gangliosides.
Glycobiology. 1998 Jun;8(6):527-32. doi: 10.1093/glycob/8.6.527.

引用本文的文献

1
Influenza B Virus Receptor Specificity: Closing the Gap between Binding and Tropism.乙型流感病毒受体特异性：弥合结合与嗜性之间的差距。
Viruses. 2024 Aug 24;16(9):1356. doi: 10.3390/v16091356.
2
Structural basis for receptor specificity of influenza B virus hemagglutinin.乙型流感病毒血凝素受体特异性的结构基础。
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16874-9. doi: 10.1073/pnas.0708363104. Epub 2007 Oct 17.
3
Animal virus receptors.动物病毒受体
Folia Microbiol (Praha). 1999;44(5):467-86. doi: 10.1007/BF02816247.
4
Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza A viruses and inhibit viral infection.合成唾液酸磷脂酰乙醇胺衍生物与人甲型流感病毒结合并抑制病毒感染。
Glycoconj J. 1998 Nov;15(11):1099-108. doi: 10.1023/a:1006961912465.
5
Sialidase of swine influenza A viruses: variation of the recognition specificities for sialyl linkages and for the molecular species of sialic acid with the year of isolation.甲型猪流感病毒的唾液酸酶：唾液酸连接以及唾液酸分子种类识别特异性随分离年份的变化。
Glycoconj J. 1995 Apr;12(2):156-61. doi: 10.1007/BF00731360.