Gadian D G, Connelly A, Duncan J S, Cross J H, Kirkham F J, Johnson C L, Vargha-Khadem F, Nevile B G, Jackson G D
Radiology and Physics Unit, Institute of Child Health, London, England.
Acta Neurol Scand Suppl. 1994;152:116-21. doi: 10.1111/j.1600-0404.1994.tb05202.x.
We have been using proton magnetic resonance spectroscopy (1H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 x 2 x 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N-acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline-containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho+Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis.
我们一直在使用质子磁共振波谱（1H MRS）来研究患有难治性癫痫的成人和儿童。波谱取自颞叶内侧区域2×2×2立方厘米的组织块，并根据N-乙酰天门冬氨酸（NAA）、肌酸+磷酸肌酸（Cr）以及含胆碱化合物（Cho）的信号进行分析。与对照组相比，癫痫患者组的NAA信号和NAA/Cho+Cr比值显著降低，而Cho和Cr信号增加。NAA的降低被解释为神经元丢失或损伤，而Cr和Cho信号的增加可能反映了反应性星形细胞增生。
