Loke S L, Ma L, Wong M, Srivastava G, Lo I, Bird C C
Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
J Clin Pathol. 1990 Nov;43(11):909-12. doi: 10.1136/jcp.43.11.909.
Thirty seven cases of oesophageal squamous cell carcinoma were studied by applying DNA slot blot analysis and in situ hybridisation using type specific probes for HPV 6, 11, 16 and 18. Cases of condyloma accuminata, cervical carcinoma, and laryngeal papilloma were used as controls. Blocks including areas of invasive carcinoma, intraepithelial neoplasia, and normal epithelium were studied in each case. No HPV genome was detectable in any of the oesophageal cases. It is concluded that these types of HPV do not have an association with oesophageal squamous cell carcinoma.
应用DNA斑点印迹分析以及使用针对人乳头瘤病毒（HPV）6、11、16和18型的型特异性探针进行原位杂交，对37例食管鳞状细胞癌进行了研究。尖锐湿疣、宫颈癌和喉乳头状瘤病例用作对照。对每例病例中包括浸润癌、上皮内瘤变和正常上皮区域的组织块进行了研究。在任何食管病例中均未检测到HPV基因组。得出的结论是，这些类型的HPV与食管鳞状细胞癌无关。
