Yamamoto J H, Minami M, Inaba G, Masuda K, Mochizuki M
Department of Ophthalmology, School of Medicine, University of Tokyo, Japan.
Br J Ophthalmol. 1993 Sep;77(9):584-9. doi: 10.1136/bjo.77.9.584.
The notion that autoimmune mechanisms play a role in the pathogenesis of certain uveitic conditions in humans is supported by the observation that lymphocytes from such patients respond in culture against retinal specific antigens which are uveitogenic in animals. A large proportion of uveitis patients with Behçet's disease are reported to respond well to S antigen, to interphotoreceptor retinoid binding protein (IRBP) and to several of their uveitogenic peptides, in particular, the S antigen derived peptide M. Patients with Behçet's disease without ocular involvement were reported not to differ in their responses to S antigen from the responses in the control group, yet 35% of them responded to IRBP and approximately two thirds of them responded to the peptides (peptide M, peptide N, R-4, or R-14). The responses were inhibited by monoclonal antibodies to CD4 and to class II MHC HLA-DR molecules. The presence of lymphocyte responses to retinal antigens in patients with Behçet's disease without uveitis might indicate a preclinical stage of ocular involvement. Thus, these data support the idea that autoimmunity to retinal specific antigens may play a role in the ocular inflammation in Behçet's disease.
自身免疫机制在人类某些葡萄膜炎病症的发病机制中起作用这一观点，得到了以下观察结果的支持：此类患者的淋巴细胞在培养中对视网膜特异性抗原产生反应，而这些抗原在动物中具有致葡萄膜炎性。据报道，很大一部分白塞病葡萄膜炎患者对S抗原、光感受器间类视黄醇结合蛋白（IRBP）及其几种致葡萄膜炎性肽，特别是S抗原衍生肽M反应良好。据报道，无眼部受累的白塞病患者对S抗原的反应与对照组无差异，但其中35%对IRBP有反应，约三分之二对这些肽（肽M、肽N、R - 4或R - 14）有反应。这些反应受到抗CD4单克隆抗体和抗II类MHC HLA - DR分子单克隆抗体的抑制。无葡萄膜炎的白塞病患者存在对视网膜抗原的淋巴细胞反应，这可能表明存在眼部受累的临床前期。因此，这些数据支持了针对视网膜特异性抗原的自身免疫可能在白塞病眼部炎症中起作用这一观点。
