Shirahashi H, Murakami N, Watanabe M, Nagatsu A, Sakakibara J, Tokuda H, Nishino H, Iwashima A
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Chem Pharm Bull (Tokyo). 1993 Sep;41(9):1664-6. doi: 10.1248/cpb.41.1664.
Bioassay-directed fractionation of the extract of the cyanobacterium P. tenue led to the isolation of the three classes of glycolipids, viz., monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG), and sulfoquinovosyl diacylglycerol (SQDG) as anti-tumor-promoters. In comparing the anti-tumor-promoting effect of the three classes of glycolipids with various acyl residues, MGDG and DGDG inhibited tumor promotion more intensely than SQDG. With respect to MGDG and DGDG, the inhibitory activity of each glycolipid possessing a single pair of acyl residues was also investigated after HPLC separation. Among the 17 tested MGDGs (1a--h) and DGDGs (2a--i), three of the DGDGs (2a, b, e) showed more potent inhibitory activity toward tumor promotion than the others.
对蓝藻纤细席藻提取物进行生物测定导向的分级分离，得到了三类糖脂，即单半乳糖基二酰基甘油（MGDG）、双半乳糖基二酰基甘油（DGDG）和磺基喹喔啉基二酰基甘油（SQDG），它们具有抗肿瘤促进作用。在比较具有不同酰基残基的这三类糖脂的抗肿瘤促进作用时，MGDG和DGDG比SQDG更强烈地抑制肿瘤促进。关于MGDG和DGDG，在高效液相色谱分离后，还研究了每种具有一对酰基残基的糖脂的抑制活性。在测试的17种MGDG（1a - h）和DGDG（2a - i）中，三种DGDG（2a、b、e）对肿瘤促进的抑制活性比其他的更强。
