Dandona L, Quigley H A, Jampel H D
Wilmer Ophthalmological Institute, Johns Hopkins University, School of Medicine, Baltimore.
Am J Ophthalmol. 1989 Oct 15;108(4):414-21. doi: 10.1016/s0002-9394(14)73309-4.
We evaluated the reliability of optic disk area and disk rim area measurements obtained with the Humphrey Retinal Analyzer from ten repeat fundus images each of one eye of ten normal subjects and ten subjects with increased intraocular pressure. Variability of rim and disk areas was not significantly different between these two groups (P greater than .05), nor was it significantly different between images acquired during the same session and those acquired during different sessions (P greater than .05). Variability was significantly different between subject groups based on the distinctness of the disk edge and the slope of the cup wall (P less than .01). The average minimum change in the measurements on the same eye that would exceed variability of the technique at the 95% confidence level was 0.20 mm2 and 0.47 mm2 for rim area for the least variable and most variable subject groups based on optic nerve head characteristics, and 0.09 mm2 and 0.32 mm2 for disk area for the corresponding subject groups. Operator input contributed significantly to overall variability. Reliability of rim and disk areas in this study was comparable to that reported for other computerized image analyzers.
我们评估了使用Humphrey视网膜分析仪从10名正常受试者和10名眼压升高受试者的单眼各10次重复眼底图像中获得的视盘面积和盘缘面积测量值的可靠性。这两组之间盘缘和视盘面积的变异性无显著差异（P大于0.05），在同一会话期间采集的图像与不同会话期间采集的图像之间也无显著差异（P大于0.05）。基于视盘边缘的清晰度和杯壁的斜率，不同受试者组之间的变异性有显著差异（P小于0.01）。根据视神经乳头特征，在95%置信水平下，同一眼睛测量值中超过该技术变异性的平均最小变化，对于变异性最小和最大的受试者组，盘缘面积分别为0.20平方毫米和0.47平方毫米，相应受试者组的视盘面积分别为0.09平方毫米和0.32平方毫米。操作员输入对总体变异性有显著影响。本研究中盘缘和视盘面积的可靠性与其他计算机化图像分析仪报告的可靠性相当。
