Abeck D, Brandt O, Weichenthal M, Kowalzick L, Mensing H
Hautklinik, Universitäts-Krankenhaus Eppendorf, Hamburg.
Hautarzt. 1993 Oct;44(10):670-3.
Herpes simplex virus (HSV) infections causing severe disease are reported frequently in patients suffering from human immunodeficiency virus (HIV) infection. This disease pattern may also be seen in an immunocompromised disease state with other causes, however, as in the case presented in this paper. An 84-year-old woman had hepatic cirrhosis resulting from chronic hepatitis C virus infection. The woman developed ulcerative lesions in and around her mouth and in the genito-anal region, and these persisted for some months. Diagnosis of HSV infection was not obtained until after extensive laboratory investigations. Aciclovir infusion therapy started immediately afterwards led to dramatic improvement of the skin and mucous membrane changes. Complete clearing of lesions was not obtained, however, because the patient died as a result of the immunosuppression.
据报道，在感染人类免疫缺陷病毒（HIV）的患者中，单纯疱疹病毒（HSV）感染引发严重疾病的情况屡见不鲜。然而，在其他原因导致的免疫功能低下疾病状态中，也可能出现这种疾病模式，就像本文所呈现的病例一样。一名84岁女性因慢性丙型肝炎病毒感染而患有肝硬化。该女性在口腔及其周围以及生殖器 - 肛门区域出现溃疡性病变，且这些病变持续了数月之久。直到经过广泛的实验室检查后，才确诊为HSV感染。随后立即开始的阿昔洛韦静脉输注治疗使皮肤和黏膜病变得到显著改善。然而，由于患者因免疫抑制而死亡，病变并未完全清除。
