Erdman D D, Heath J L, Watson J C, Markowitz L E, Bellini W J
Respiratory and Enterovirus Branch, Centers for Disease Control, Atlanta, GA 30333.
J Med Virol. 1993 Sep;41(1):44-8. doi: 10.1002/jmv.1890410110.
The use of IgM antibody detection for the classification of the primary and secondary measles antibody response in persons following primary and secondary vaccination and natural measles virus infection was examined. Of 32 nonimmune children receiving primary measles vaccination, 31 (97%) developed IgM antibodies, consistent with a primary antibody response. Of 21 previously vaccinated children with low levels of preexisting IgG antibodies who responded to revaccination, none developed detectable IgM antibodies, whereas 33 of 35 (94%) with no detectable preexisting IgG antibodies developed an IgM response. Of a sample of 57 measles cases with a prior history of vaccination, 55 (96%) had detectable IgM antibodies. Of these, 30 (55%) were classified as having a primary antibody response and 25 (45%) a secondary antibody response based on differences in their ratios of IgM to IgG antibodies. Differences in the severity of clinical symptoms between these 2 groups were consistent with this classification scheme. These findings suggest that 1) an IgM response follows primary measles vaccination in the immunologically naive, 2) an IgM response is absent on revaccination of those previously immunized, and 3) an IgM response may follow clinical measles virus infection independent of prior immunization status.
研究了使用IgM抗体检测对初次和二次接种疫苗以及自然感染麻疹病毒后的人群中初次和二次麻疹抗体反应进行分类的情况。在32名接受初次麻疹疫苗接种的非免疫儿童中，31名（97%）产生了IgM抗体，符合初次抗体反应。在21名先前接种过疫苗但预先存在的IgG抗体水平较低且对再次接种有反应的儿童中，无人产生可检测到的IgM抗体，而在35名未检测到预先存在的IgG抗体的儿童中，33名（94%）产生了IgM反应。在57例有疫苗接种史的麻疹病例样本中，55例（96%）有可检测到的IgM抗体。其中，根据IgM与IgG抗体比例的差异，30例（55%）被分类为具有初次抗体反应，25例（45%）为二次抗体反应。这两组临床症状严重程度的差异与该分类方案一致。这些发现表明：1）在免疫未成熟个体中，初次麻疹疫苗接种后会出现IgM反应；2）先前免疫过的个体再次接种时不会出现IgM反应；3）IgM反应可能在临床感染麻疹病毒后出现，与先前的免疫状态无关。
