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MutY修复在大肠杆菌的mutT -菌株中具有致突变性。

MutY repair is mutagenic in mutT- strains of Escherichia coli.

作者信息

Vidmar J J, Cupples C G

机构信息

Biology Department, Concordia University, West, Montréal, PQ, Canada.

出版信息

Can J Microbiol. 1993 Sep;39(9):892-4. doi: 10.1139/m93-133.

DOI:10.1139/m93-133
PMID:8242489
Abstract

We have determined the numbers and types of mutations that occur in strains of Escherichia coli defective in mutT and (or) mutY repair. High rates of C.G to A.T mutations in mutY- cells are unaffected by the status of mutT. However, mutT-/mutY+ strains have higher rates of A.T to C.G mutations than mutT-/mutY- strains. This result indicates that the high rates of A.T to C.G mutations seen in mutT- strains of E. coli are due in part to the activity of the mutY repair system. We conclude that mutY repair is mutagenic in a mutT- background.

摘要

我们已经确定了在mutT和（或）mutY修复缺陷的大肠杆菌菌株中发生的突变数量和类型。mutY-细胞中C.G到A.T突变的高发生率不受mutT状态的影响。然而，mutT-/mutY+菌株比mutT-/mutY-菌株具有更高的A.T到C.G突变率。这一结果表明，在大肠杆菌mutT-菌株中看到的高频率A.T到C.G突变部分归因于mutY修复系统的活性。我们得出结论，在mutT-背景下，mutY修复具有致突变性。

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1
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