Schmitz-Moormann P, Hein J
Virchows Arch A Pathol Anat Histol. 1976 Aug 23;371(2):145-52. doi: 10.1007/BF00444930.
A postmortem study by ductography and histology was carried out in 50 macroscopically normal human pancreata. The alterations of the pancreatic duct system, their relations to the parenchyma, and their changes depending on age were studied. The most frequent changes of the ducts are epithelial hyperplasia (88%) and periductal fibrosis (74%). In the ducts they produce cystic widening (62%) and intraluminal protein precipitates (40%), within the parenchyma an intralobular fibrosis up to total fibrosis of lobules (88%). All these alterations increase with aging both in frequency and intensity. But they are already visible before the age of 50 and sometimes before the age of 30. The pathogenetic connexions between the changes of the duct system and the alterations of parenchyma were studied by serial sections and ceroplasty. This investigation revealed that the small branches of the larger ducts, which drain small periductally situated lobules, play an important role in the development of the parenchymal alterations. No connections were found between the pancreatic alterations and diseases of the bile duct system.
对50个大体正常的人体胰腺进行了胰管造影和组织学的尸检研究。研究了胰腺导管系统的改变、它们与实质的关系以及随年龄的变化。导管最常见的变化是上皮增生（88%）和导管周围纤维化（74%）。在导管内，它们导致囊性扩张（62%）和管腔内蛋白质沉淀（40%），在实质内则导致小叶内纤维化直至小叶完全纤维化（88%）。所有这些改变随年龄增长在频率和强度上均增加。但在50岁之前甚至有时在30岁之前就已可见。通过连续切片和整形术研究了导管系统变化与实质改变之间的发病学联系。该研究表明，引流导管周围小小叶的较大导管的小分支在实质改变的发展中起重要作用。未发现胰腺改变与胆管系统疾病之间存在关联。
