健康成年人经口吸入和经鼻吸入后肺部雾化气溶胶沉积的比较。
Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation.
作者信息
Everard M L, Hardy J G, Milner A D
机构信息
Department of Child Health, Queens Medical Centre, Nottingham.
出版信息
Thorax. 1993 Oct;48(10):1045-6. doi: 10.1136/thx.48.10.1045.
Abstract
A standard jet nebuliser was used to generate a radiolabelled aerosol and the pattern of deposition within the airways of eight healthy adults was studied with a gamma camera. Penetration of aerosol to the lung was greatly reduced when breathing through the nose compared with mouth breathing.
摘要
使用标准喷射雾化器产生放射性标记气雾剂，并使用伽马相机研究了八名健康成年人气道内的沉积模式。与经口呼吸相比，经鼻呼吸时气雾剂进入肺部的程度大大降低。
相似文献
1
Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation.健康成年人经口吸入和经鼻吸入后肺部雾化气溶胶沉积的比较。
Thorax. 1993 Oct;48(10):1045-6. doi: 10.1136/thx.48.10.1045.
2
A Trans-Nasal Aerosol Delivery Device for Efficient Pulmonary Deposition.一种用于高效肺部沉积的经鼻气溶胶递送装置。
J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):223-229. doi: 10.1089/jamp.2016.1333. Epub 2017 Feb 3.
3
Lung aerosol deposition in suckling infants.婴幼儿肺部气溶胶沉积。
Arch Dis Child. 2012 Jun;97(6):497-501. doi: 10.1136/archdischild-2011-301236. Epub 2012 Feb 23.
4
Aerosol deposition and clearance measurement: a novel technique using dynamic SPET.气溶胶沉积与清除测量：一种使用动态单光子发射计算机断层扫描的新技术。
Eur J Nucl Med. 2001 Sep;28(9):1365-72. doi: 10.1007/s002590100586.
5
Nasally inhaled pulsating aerosols: lung, sinus and nose deposition.经鼻吸入式脉动气雾剂：肺部、鼻窦和鼻腔沉积。
Rhinology. 2011 Aug;49(3):286-91. doi: 10.4193/Rhino10.268.
6
In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology.利用混合谐振声学（HYDRA）技术的新一代雾化器体内沉积研究。
Int J Pharm. 2020 Apr 30;580:119196. doi: 10.1016/j.ijpharm.2020.119196. Epub 2020 Mar 4.
7
Deposition of aerosols delivered by nasal route with jet and mesh nebulizers.经鼻喷射和网孔雾化器输送的气溶胶沉积。
Int J Pharm. 2011 Apr 4;407(1-2):87-94. doi: 10.1016/j.ijpharm.2011.01.024. Epub 2011 Jan 21.
8
The influence of age on aerosol deposition in children with cystic fibrosis.年龄对囊性纤维化患儿气溶胶沉积的影响。
Eur Respir J. 1994 Dec;7(12):2185-91. doi: 10.1183/09031936.94.07122185.
9
SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study.使用振动网式雾化器与带阀储雾罐相结合的系统和传统喷射雾化器进行肺部沉积的SPECT-CT比较：一项随机交叉研究。
Pharm Res. 2017 Feb;34(2):290-300. doi: 10.1007/s11095-016-2061-7. Epub 2016 Nov 7.
10
Mode of breathing-tidal or slow and deep-through the I-neb Adaptive Aerosol Delivery (AAD) system affects lung deposition of (99m)Tc-DTPA.通过 I-neb 自适应雾化输送（AAD）系统进行的呼吸模式——潮汐式或缓慢而深沉——会影响（99m）Tc-DTPA 在肺部的沉积。
J Aerosol Med Pulm Drug Deliv. 2010 Apr;23 Suppl 1(Suppl 1):S37-43. doi: 10.1089/jamp.2009.0786.
引用本文的文献
1
The bacterial burden of worn face masks-observational research and literature review.使用过的口罩上的细菌负荷——观察性研究与文献综述
Front Public Health. 2024 Dec 3;12:1460981. doi: 10.3389/fpubh.2024.1460981. eCollection 2024.
2
The effects of airway disease on the deposition of inhaled drugs.气道疾病对吸入药物沉积的影响。
Expert Opin Drug Deliv. 2024 Aug;21(8):1175-1190. doi: 10.1080/17425247.2024.2392790. Epub 2024 Aug 19.
3
A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity.一种新型的原位方法来测定碳质颗粒在呼吸道中的沉积，揭示了在高度污染的特大城市中公众通勤的危害。
Part Fibre Toxicol. 2022 Sep 15;19(1):61. doi: 10.1186/s12989-022-00501-x.
4
Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI.使用喷雾干燥抗生素制剂和儿科空气射流干粉吸入器，近乎消除儿童体外预测的胸腔外气溶胶沉积。
Pharm Res. 2023 May;40(5):1193-1207. doi: 10.1007/s11095-022-03316-9. Epub 2022 Jun 27.
5
High-Efficiency Dry Powder Aerosol Delivery to Children: Review and Application of New Technologies.向儿童高效递送干粉气雾剂：新技术综述与应用
J Aerosol Sci. 2021 Mar;153. doi: 10.1016/j.jaerosci.2020.105692. Epub 2020 Oct 14.
6
The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways.经口呼吸和经鼻呼吸对吸入颗粒物在上呼吸道和气管支气管气道中沉积的影响。
J Aerosol Sci. 2020 Dec;150:105649. doi: 10.1016/j.jaerosci.2020.105649. Epub 2020 Aug 28.
7
Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children.开发一种用于儿童口服或经鼻气溶胶给药的在线干粉吸入器。
J Aerosol Med Pulm Drug Deliv. 2020 Apr;33(2):83-98. doi: 10.1089/jamp.2019.1540. Epub 2019 Aug 29.
8
Nebulizer practices among paramedics in India.印度护理人员的雾化器使用情况。
Lung India. 2019 Jan-Feb;36(1):80-81. doi: 10.4103/lungindia.lungindia_147_18.
9
Effect of Inhaled Nebulized Furosemide (40 and 120 mg) on Breathlessness during Exercise in the Presence of External Thoracic Restriction in Healthy Men.吸入雾化速尿（40毫克和120毫克）对健康男性在存在胸廓外部限制时运动期间呼吸困难的影响。
Front Physiol. 2018 Feb 12;9:86. doi: 10.3389/fphys.2018.00086. eCollection 2018.
10
Inhalation therapy in mechanical ventilation.机械通气中的吸入疗法。
J Bras Pneumol. 2015 Sep-Oct;41(5):467-72. doi: 10.1590/S1806-37132015000000035.
本文引用的文献
1
Facemask or mouthpiece for delivery of nebulized bronchodilator aerosols?用于递送雾化支气管扩张剂气雾剂的面罩还是口含器？
Br J Dis Chest. 1981 Jan;75(1):88-90. doi: 10.1016/s0007-0971(81)80012-5.
2
Quantitative comparison of 99Tcm-aerosol and 81Krm ventilation images.
Clin Phys Physiol Meas. 1982 Feb;3(1):21-30. doi: 10.1088/0143-0815/3/1/002.
3
Droplet size distributions of nebulised aerosols for inhalation therapy.用于吸入治疗的雾化气雾剂的液滴大小分布。
Clin Phys Physiol Meas. 1986 May;7(2):139-46. doi: 10.1088/0143-0815/7/2/004.
4
Deposition of carbenicillin aerosols in cystic fibrosis: effects of nebuliser system and breathing pattern.羧苄青霉素气雾剂在囊性纤维化中的沉积：雾化器系统和呼吸模式的影响。
Thorax. 1988 Apr;43(4):318-22. doi: 10.1136/thx.43.4.318.
5
Delivery of albuterol and ipratropium bromide from two nebulizer systems in chronic stable asthma. Efficacy and pulmonary deposition.两种雾化器系统在慢性稳定型哮喘中递送沙丁胺醇和异丙托溴铵的效果及肺部沉积情况
Chest. 1989 Jul;96(1):6-10. doi: 10.1378/chest.96.1.6.
6
Drug delivery from jet nebulisers.来自喷射式雾化器的药物递送。
Arch Dis Child. 1992 May;67(5):586-91. doi: 10.1136/adc.67.5.586.
7
Two methods of administering nebulized salbutamol: a controlled study.两种雾化吸入沙丁胺醇的给药方法：一项对照研究。
Aust Paediatr J. 1978 Sep;14(3):150-3. doi: 10.1111/jpc.1978.14.3.150.
8
Response of asthmatic patients to fenoterol inhalation: a method of quantifying the airway bronchodilator dose.哮喘患者对非诺特罗吸入的反应：一种量化气道支气管扩张剂剂量的方法。
Clin Pharmacol Ther. 1978 Mar;23(3):338-45. doi: 10.1002/cpt1978233338.
Zotero 插件