Hamdy F M, Dardiri A H, Nduaka O, Breese S S, Ihemelandu E C
Can J Comp Med. 1976 Jul;40(3):276-84.
The causative agent of stomatitis pneumoenteritis complex was isolated in domesticated goats and Vero cell culture. It was identified immunologically and morphologically as identical with the "Peste des Petits Ruminants" virus. There were cross reactions between stomatitis pneumoenteritis complex virus isolate and rinderpest virus by immunodiffusion and complement fixation tests but no cross neutralization. Goats recovered from stomatitis pneumoenteritis complex were protected against a challenge with rinderpest virus that was lethal to control goats. Ultrastructural morphology revealed intracytoplasmic and intranuclear inclusions made up of random arrays of fibrillar strands. Pleomorphic particles budded from the plasma membrane of infected cells and enveloped virions were seen extracellularly. Specific ferritin tagging was demonstrated in the stomatitis pneumoenteritis complex virus infected cells treated with homologous and peste des petits ruminants viral antibody systems but little, if any, tagging in the heterologous rinderpest system.
口炎肺炎肠炎综合征的病原体是在圈养山羊和Vero细胞培养物中分离出来的。通过免疫和形态学鉴定，它与“小反刍兽疫”病毒相同。通过免疫扩散和补体结合试验，口炎肺炎肠炎综合征病毒分离株与牛瘟病毒之间存在交叉反应，但无交叉中和作用。从口炎肺炎肠炎综合征中康复的山羊对牛瘟病毒的攻击具有抵抗力，而这种攻击对对照山羊是致命的。超微结构形态显示，胞浆内和核内包涵体由随机排列的纤维状链组成。多形性颗粒从受感染细胞的质膜上芽生，胞外可见有包膜的病毒粒子。在用同源和小反刍兽疫病毒抗体系统处理的口炎肺炎肠炎综合征病毒感染细胞中显示出特异性铁蛋白标记，但在异源牛瘟系统中标记很少（如果有的话）。
