Teff K L, Mattes R D, Engelman K
Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia 19104.
Am J Physiol. 1991 Oct;261(4 Pt 1):E430-6. doi: 10.1152/ajpendo.1991.261.4.E430.
The existence and reliability of cephalic phase insulin release (CPIR) were tested in 20 normal weight males. Each subject was challenged three times with the same food stimulus over a 5-day period. Four baseline blood samples were taken at 5-min intervals before food ingestion and then every 2 min for 16 min postingestion. Significant increases in plasma insulin were found at 4 min postingestion on each trial day. CPIR was found to be highly reproducible between trials (r = 0.83; P less than 0.001). Fifty percent of the subjects exhibited a significant increase of plasma insulin above their own baseline mean on the first trial, whereas 75 and 72% exhibited increases on trials 2 and 3, respectively. Only two subjects (10%) did not demonstrate a response on any trial. A significant decline in plasma glucose was observed at 4 min postingestion on trials 2 and 3. No significant changes in plasma glucagon were found during any trial day. This study confirms a reliable CPIR in normal weight males.
在20名正常体重男性中测试了头期胰岛素释放（CPIR）的存在及可靠性。在5天的时间里，每位受试者用相同的食物刺激进行了三次挑战。在进食前每隔5分钟采集4份基线血样，然后在进食后每隔2分钟采集血样，共采集16分钟。在每个试验日进食后4分钟时，血浆胰岛素显著升高。发现CPIR在各试验之间具有高度可重复性（r = 0.83；P < 0.001）。50%的受试者在第一次试验时血浆胰岛素较自身基线平均值有显著升高，而在第二次和第三次试验时，分别有75%和72%的受试者出现升高。只有两名受试者（10%）在任何一次试验中均未表现出反应。在第二次和第三次试验的进食后4分钟时，观察到血浆葡萄糖显著下降。在任何试验日期间，血浆胰高血糖素均未发现显著变化。本研究证实了正常体重男性中存在可靠的CPIR。
