柱状上皮化生的巴雷特食管中的胆汁反流。
Bile reflux in columnar-lined Barrett's oesophagus.
作者信息
Iftikhar S Y, Ledingham S, Steele R J, Evans D F, Lendrum K, Atkinson M, Hardcastle J D
机构信息
Department of Surgery, University Hospital, Nottingham.
出版信息
Ann R Coll Surg Engl. 1993 Nov;75(6):411-6.
Abstract
Total and individual bile acid concentrations in the oesophageal aspirates from 30 patients with Barrett's oesophagus were compared with those from 15 patients with oesophagitis and 15 normal subjects. The highest total bile acid concentrations were found in the Barrett's patients and this was statistically significant when compared with controls but not oesophagitis patients. However, when the 95th percentile value of bile acid concentration in the normal subjects was taken as the 'cut-off' level, a significantly higher number of Barrett's patients (15/30) were bile refluxers than were the oesophagitis patients (3/15). Glycocholic and taurocholic acids were the predominant bile acids detected, but taurochenodeoxycholic acid was also present in significant amounts in the patients with oesophagitis. It is possible that bile reflux contributes to the development of Barrett's oesophagus.
摘要
对30例巴雷特食管患者、15例食管炎患者及15名正常受试者食管吸出物中的总胆汁酸浓度和各胆汁酸浓度进行了比较。巴雷特食管患者的总胆汁酸浓度最高，与对照组相比具有统计学意义，但与食管炎患者相比无统计学意义。然而，以正常受试者胆汁酸浓度的第95百分位数作为“临界”水平时，巴雷特食管患者中胆汁反流者的数量（15/30）明显高于食管炎患者（3/15）。检测到的主要胆汁酸为甘氨胆酸和牛磺胆酸，但牛磺鹅去氧胆酸在食管炎患者中也大量存在。胆汁反流可能促使巴雷特食管的发生。
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