Okamoto Y, Minami S, Matsuhashi A, Sashiwa H, Saimoto H, Shigemasa Y, Tanigawa T, Tanaka Y, Tokura S
Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Japan.
J Vet Med Sci. 1993 Oct;55(5):743-7. doi: 10.1292/jvms.55.743.
The sponge-, cotton-, and flake-type remedies made of chitin (chitin-sponge, chitin-cotton, and chitin-flake, respectively), and non-woven fabric of polyester (NWF) composited with chitin (chitin-NWF) were applied to various types of trauma, abscess, surgical tissue defect and herniorrhaphy in 147 clinical cases including 72 dogs, 38 cows, 33 cats, 2 rabbits, one monkey and one horse. Chitin-sponge was applied in 30 cases as filling agent of surgical tissue defect, and in 25 cases of trauma, 31 cases of abscess as wound dressing or tissue defect filling agent. In 77 out of 86 cases (89.5%), good healing developed. When chitin-sponge was buried in surgical tissue defects due to oncotomy in 20 cases, recurrence of the tumor developed in one case on one month post-operatively, but was not recognized for 3-24 months in 19 cases. Chitin-NWF was applied in 2 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent, 6 cases as filling agent of surgical tissue defect, and 12 cases of umbilical hernia as prosthesis of suture site of hernia ring. In 28 out of 32 cases (87.5%), good healing developed. Chitin-cotton was applied in 8 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent. In 18 out of 20 cases (90.0%), good healing developed. Chitin-flake was applied in 9 cases of trauma as wound dressing or tissue defect filling agent. In 8 out of 9 cases (88.9%), good healing developed. In all cases, no side effects were observed.
分别由几丁质制成的海绵型、棉型和薄片型治疗剂（分别为几丁质海绵、几丁质棉和几丁质薄片），以及与几丁质复合的聚酯无纺布（NWF）（几丁质-NWF）被应用于147例临床病例的各类创伤、脓肿、手术组织缺损和疝修补术，其中包括72只犬、38头牛、33只猫、2只兔、1只猴和1匹马。几丁质海绵作为手术组织缺损填充剂应用于30例，作为创伤治疗应用于25例，作为脓肿伤口敷料或组织缺损填充剂应用于31例。86例中有77例（89.5%）愈合良好。20例因肿瘤切除导致手术组织缺损而植入几丁质海绵时，术后1个月有1例肿瘤复发，但19例在3至24个月未出现复发。几丁质-NWF作为创伤治疗应用于2例、作为脓肿伤口敷料或组织缺损填充剂应用于12例，作为手术组织缺损填充剂应用于6例，作为脐疝疝环缝合部位假体应用于12例脐疝。32例中有28例（87.5%）愈合良好。几丁质棉作为创伤治疗应用于8例、作为脓肿伤口敷料或组织缺损填充剂应用于12例。20例中有18例（90.0%）愈合良好。几丁质薄片作为创伤治疗应用于9例，作为伤口敷料或组织缺损填充剂。9例中有8例（88.9%）愈合良好。所有病例均未观察到副作用。
