Karp B I, Cole R A, Cohen L G, Grill S, Lou J S, Hallett M
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892.
Neurology. 1994 Jan;44(1):70-6. doi: 10.1212/wnl.44.1.70.
We treated focal hand dystonia in 53 patients with botulinum toxin injections for up to 6 years. Eighty-one percent of the patients improved with at least one injection session. Sixty-five percent of the injections produced transient weakness. We followed 37 of the patients for at least 2 years from the start of treatment, 24 of whom discontinued treatment because of inadequate response, loss of response, inaccessibility of a treatment provider, or the expense of the toxin. Women, who had a greater extent and longer duration of benefit than men, were more likely to continue treatment. The mean interval between injection sessions was 6 months. In most patients, we injected the toxin into the same combination of muscles at each session. The dose of toxin generally fluctuated within a range of 20 units. Side effects were mild and transient and unrelated to the long-term use of botulinum toxin. Botulinum toxin injection is safe and effective for the long-term management of focal hand dystonia.
我们对53例局限性手部肌张力障碍患者进行了肉毒毒素注射治疗，最长达6年。81%的患者在至少一次注射疗程后病情改善。65%的注射产生了短暂性无力。我们从治疗开始对37例患者进行了至少2年的随访，其中24例因疗效不佳、疗效丧失、无法获得治疗服务或毒素费用等原因停止治疗。女性比男性受益程度更大、持续时间更长，更有可能继续治疗。注射疗程之间的平均间隔为6个月。在大多数患者中，我们每次注射时都将毒素注入相同的肌肉组合。毒素剂量一般在20单位范围内波动。副作用轻微且短暂，与肉毒毒素的长期使用无关。肉毒毒素注射对于局限性手部肌张力障碍的长期管理是安全有效的。
