Rindum J L, Holmstrup P, Pedersen M, Rassing M R, Stoltze K
Department of Oral Medicine and Oral Surgery, University Hospital (Rigshospitalet), Copenhagen, Denmark.
Scand J Dent Res. 1993 Dec;101(6):386-90. doi: 10.1111/j.1600-0722.1993.tb01137.x.
A chewing gum containing the antifungal drug miconazole may be convenient for topical treatment of oral candidosis. Therefore a trial was performed to examine the effect and tolerance of miconazole chewing gum in comparison with miconazole gel in the treatment of oral candidosis. The study group consisted of 32 patients with oral candidosis harboring yeasts, predominantly Candida spp. Half of the patients chewed one piece of chewing gum (dose: 3.6 mg of miconazole) four times daily; the other half dispersed a 2% gel (dose: 50 mg of miconazole) in the oral cavity four times daily. After 6 wk of treatment, there was no clinical evidence of yeast infection in either of the two groups. No significant differences between the two groups were found in clinical, mycologic, and cytologic investigations conducted after 3 and 6 wk of treatment or at the follow-up examination 4 wk after termination of the treatment. The results indicate that miconazole released from chewing gum is as effective as miconazole gel. The chewing gum reduced the dosage of miconazole for treatment of oral candidosis, and the patients approved the chewing gum as a pleasant medicament.
含抗真菌药物咪康唑的口香糖可能便于口腔念珠菌病的局部治疗。因此，进行了一项试验，以比较咪康唑口香糖与咪康唑凝胶治疗口腔念珠菌病的效果和耐受性。研究组由32例口腔念珠菌病患者组成，主要为念珠菌属酵母。一半患者每天咀嚼一片口香糖（剂量：3.6毫克咪康唑），共4次；另一半患者每天4次在口腔内涂抹2%凝胶（剂量：50毫克咪康唑）。治疗6周后，两组均无酵母感染的临床证据。在治疗3周和6周后或治疗结束后4周的随访检查中进行的临床、真菌学和细胞学检查中，两组之间未发现显著差异。结果表明，从口香糖中释放的咪康唑与咪康唑凝胶一样有效。口香糖降低了治疗口腔念珠菌病的咪康唑剂量，患者认可口香糖是一种宜人的药物。
