Liu L, Yang D
Department of Ophthalmology, Second Military Medical University, Shanghai.
Chin Med Sci J. 1993 Jun;8(2):84-8.
Immunohistochemical, electron microscopic and routine pathological studies were conducted to observe the changes in T-cell subsets, B-cells, plasma cells, and mast cells, and the distributions of immunoglobulins (IgE, IgG, IgA, IgM) and C3 in patients with pterygium. The results were as follows. Massive amounts of infiltrating lymphocytes, predominantly T-cells (CD3+), were found in the substantia propria of the pterygial specimens. The helper-suppressor ratio had risen from 1:2.7 in the normal conjunctiva to 1:1.5. Positive cytoplasmic immunoglobulin staining indicated a plasmocytic infiltration in the lesions as well. Abnormal distributions of immunoglobulins were found, and deposition of immunoglobulins in a granular pattern around the basement membrane of the epithelial layer was seen. Mast cell reactions were found, and a linear correlation between the numbers of lymphocytes and mast cells was shown. Basement membrane destruction in the cap area of the pterygium was also confirmed. These results indicate that an immunologic mechanism, possibly of Types 1, 3 and 4 hypersensitivity, may contribute to the pathogenesis of pterygium.
进行了免疫组织化学、电子显微镜和常规病理学研究，以观察翼状胬肉患者T细胞亚群、B细胞、浆细胞和肥大细胞的变化，以及免疫球蛋白（IgE、IgG、IgA、IgM）和C3的分布。结果如下。在翼状胬肉标本的固有层中发现大量浸润淋巴细胞，主要为T细胞（CD3+）。辅助性T细胞与抑制性T细胞的比例从正常结膜中的1:2.7升至1:1.5。细胞质免疫球蛋白阳性染色表明病变中也有浆细胞浸润。发现免疫球蛋白分布异常，在上皮层基底膜周围可见颗粒状免疫球蛋白沉积。发现肥大细胞反应，且淋巴细胞数量与肥大细胞数量呈线性相关。翼状胬肉头部区域的基底膜破坏也得到证实。这些结果表明，一种可能为I型、III型和IV型超敏反应的免疫机制可能参与了翼状胬肉的发病过程。
