Jensen G V, Nielsen B
Nefrologisk afdeling, Hvidovre Hospital, København.
Ugeskr Laeger. 1994 Jan 10;156(2):183-4.
Twenty-two patients in haemodialysis were treated with erythropoietin subcutaneously in a double-blinded cross-over study with erythropoietin prepared either as a lyophilisate or an albumin-solution. The aim was to compare local reactions and pain. Both preparations were tolerated well. No major adverse reactions were seen. Erythropoietin albumin-solution was associated with significantly more burning pain than erythropoietin lyophilisate. Allergy does not seem to be involved. Albumin could be the irritative agent.
在一项双盲交叉研究中，对22名血液透析患者皮下注射促红细胞生成素，该促红细胞生成素制备成冻干制剂或白蛋白溶液。目的是比较局部反应和疼痛情况。两种制剂耐受性均良好，未观察到重大不良反应。与促红细胞生成素冻干制剂相比，促红细胞生成素白蛋白溶液引发的灼痛明显更多。似乎与过敏无关。白蛋白可能是刺激物。
