Law C L, Grierson J M, Stevens S M
Sexual Health Centre, Sydney Hospital, Australia.
Genitourin Med. 1994 Feb;70(1):26-9. doi: 10.1136/sti.70.1.26.
To determine the prevalence of rectal spirochaetosis in homosexual men attending a sexually transmissible diseases clinic and investigate the association between their presence and sexual practices, HIV infection and enteric flora.
The study included 144 male homosexual subjects who each completed a questionnaire, underwent physical examination, proctoscopy and investigations for STD and HIV screening, rectal biopsies and collection of faecal samples.
The Sexual Health Centre, Sydney Hospital, Sydney, Australia.
Spirochaetes were detected in 39% of the rectal biopsies, using histological criteria. Logistic regression analysis showed that rectal spirochaetosis was significantly associated with: oral-anal contact. (P < 0.05, OR 3.45, 95% CI 1.48-8.05); detection of 3-5 different non-pathogenic protozoa in faeces (P < 0.01, OR 11.68, 95% C.I. 2.33-58) and a positive HIV antibody test (P < 0.01) OR 4.48, 95% C.I. 1.28-15.72).
These findings indicate that rectal spirochaetosis is relatively common in homosexual men. The association with non-pathogenic protozoa is most likely attributable to the common mode of transmission viz oral-anal contact. However it is difficult to determine whether the association with HIV infection is cause or effect because of the limitations in the study design. Further information is required to determine the clinical significance of infection with these organisms.
确定在一家性传播疾病诊所就诊的男同性恋者中直肠螺旋体病的患病率，并调查其存在与性行为、HIV感染及肠道菌群之间的关联。
该研究纳入了144名男同性恋受试者，每人都填写了一份问卷，接受了体格检查、直肠镜检查以及性传播疾病和HIV筛查、直肠活检和粪便样本采集。
澳大利亚悉尼悉尼医院性健康中心。
根据组织学标准，在39%的直肠活检中检测到螺旋体。逻辑回归分析表明，直肠螺旋体病与以下因素显著相关：口交-肛交接触（P<0.05，比值比3.45，95%可信区间1.48-8.05）；粪便中检测到3-5种不同的非致病性原生动物（P<0.01，比值比11.68，95%可信区间2.33-58）以及HIV抗体检测呈阳性（P<0.01，比值比4.48，95%可信区间1.28-15.72）。
这些发现表明直肠螺旋体病在男同性恋者中相对常见。与非致病性原生动物的关联很可能归因于共同的传播方式，即口交-肛交接触。然而，由于研究设计的局限性，很难确定与HIV感染的关联是原因还是结果。需要更多信息来确定这些生物体感染的临床意义。
