牛分枝杆菌32千道尔顿蛋白抗原可诱导人细胞毒性T细胞反应。
The Mycobacterium bovis 32-kilodalton protein antigen induces human cytotoxic T-cell responses.
作者信息
Munk M E, De Bruyn J, Gras H, Kaufmann S H
机构信息
Department of Immunology, University of Ulm, Germany.
出版信息
Infect Immun. 1994 Feb;62(2):726-8. doi: 10.1128/iai.62.2.726-728.1994.
Abstract
The 30-kDa protein (P32) is a mycobacterial secreted antigen which is homologous in Mycobacterium bovis and M. tuberculosis. In vitro, P32 induced T-cell proliferation. M. tuberculosis- or P32-stimulated T-cell lines lysed macrophages pulsed with P32 or M. tuberculosis, respectively. We conclude that P32 stimulates cytotoxic T cells specifically.
摘要
30 kDa蛋白（P32）是一种分枝杆菌分泌抗原，在牛分枝杆菌和结核分枝杆菌中具有同源性。在体外，P32可诱导T细胞增殖。结核分枝杆菌或P32刺激的T细胞系分别裂解用P32或结核分枝杆菌脉冲处理的巨噬细胞。我们得出结论，P32可特异性刺激细胞毒性T细胞。
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