Munk M E, Mayer P, Anding P, Feldmann K, Kaufmann S H
Department of Immunology, University of Ulm, Germany.
Infect Immun. 1996 Mar;64(3):1078-80. doi: 10.1128/iai.64.3.1078-1080.1996.
Numbers of interleukin-12 (IL-12) producing cells were quantitated in the peripheral blood of healthy donors and tuberculosis patients by the ELISPOT assay. We observed that (i) stimulation with mycobacteria increases numbers of IL-12 producers from healthy donors and (ii) tuberculosis patients have larger numbers of IL-12 producers than healthy donors. Our data emphasize the importance of Il-12 in immunity to tuberculosis.
通过酶联免疫斑点分析(ELISPOT 测定)对健康供体和结核病患者外周血中产生白细胞介素 12(IL - 12)的细胞数量进行了定量分析。我们观察到:(i)用分枝杆菌刺激可增加健康供体中产生 IL - 12 的细胞数量;(ii)结核病患者中产生 IL - 12 的细胞数量比健康供体更多。我们的数据强调了 IL - 12 在结核病免疫中的重要性。