Lüer W, Gerhards J, Poser S, Weber T, Felgenhauer K
Department of Neurology, Georg-August University, Göttingen, Germany.
J Neurol Neurosurg Psychiatry. 1994 Jan;57(1):105-7. doi: 10.1136/jnnp.57.1.105.
The clinical, neuroradiological, and cerebrospinal fluid findings of a case with acute diffuse leukoencephalitis, a demyelinating disease associated with human immunodeficiency virus infection of the brain, is reported. The patient presented with acute tetraparesis as the primary manifestation of a previously symptom free HIV infection. Cerebrospinal fluid analysis showed enhanced inflammatory abnormalities with high concentrations of P24 antigen. MRI showed diffuse white matter hyper-intensities in both hemispheres. In the follow up over 22 months, the neurological deficits disappeared after antiretroviral treatment in good correlation with improvements in MRI as well as in inflammatory cerebrospinal fluid abnormalities.
报告了一例急性播散性脑白质炎患者的临床、神经放射学和脑脊液检查结果，该疾病是一种与人类免疫缺陷病毒脑感染相关的脱髓鞘疾病。患者以急性四肢轻瘫为首发表现，此前无症状的HIV感染。脑脊液分析显示炎症异常增强，P24抗原浓度升高。MRI显示双侧半球弥漫性白质高信号。在22个月的随访中，抗逆转录病毒治疗后神经功能缺损消失，与MRI改善以及脑脊液炎症异常改善密切相关。
