Ali M, Angelo-Khattar M, Farid A, Hassan R A, Thulesius O
Department of Clinical Physiology, Faculty of Health Sciences, University Hospital, Linkoping, Sweden.
Prostaglandins Leukot Essent Fatty Acids. 1993 Nov;49(5):855-9. doi: 10.1016/0952-3278(93)90210-n.
The prostaglandins (PGs) synthesized from C14-arachidonic acid by the homogenized sheep ureter were identified as being prostacyclin (PGI2), PGF2 alpha and thromboxane B2 (TXB2). The radioimmunoassay (RIA) estimation of 6-keto-PGF1 alpha, a stable metabolite of PGI2, confirms that it was the major metabolite of arachidonic acid. Aqueous extracts of fresh garlic (5, 12.5, 25 and 50 mg/ml) were shown to inhibit the synthesis of the prostanoids in a dose dependent manner. Fresh garlic extracts (1, 2.5, 5 and 10 mg/ml) also dose dependently inhibited spontaneous rhythmic contractions of the isolated ureter. Boiled garlic (5, 12.5, 25 and 50 mg/ml) had no effect on either ureteral motility or the PG synthesizing capacity of the sheep ureter.
