Maderazo D G, Ward P A, Woronick C L, Quintiliani R
J Lab Clin Med. 1977 Jan;89(1):190-9.
A leukotactic defect is described in a man with a low cerebrospinal fluid leukocyte count in the presence of an acute listeria meningitis. On the basis of subsequent studies with his serum and normal human serum, a leukotactic inhibitor has been identified. This inhibitor, termed the cell-directed inhibitor (CDI), is relatively heat stable and nondialyzable. By ultracentrifugal analysis in sucrose density gradient, the inhibitor has been resolved into two activities with estimated sedimentation coefficients of 7 and 10 S. It interacts directly with neutrophils and monocytes to render them chemotactically defective. CDI also impairs the phagocytic function of neutrophils. Evidence is presented that an antagonist to the inhibitor is present in normal serum. CDI and its antagonist are probably normally occurring regulators of leukotaxis. In the patient studied, an elevated CDI serum level may be related to the development of the listeria infection and failure of cutaneous response to skin test antigens.
一名患有急性李斯特菌脑膜炎但脑脊液白细胞计数低的男性被发现存在白细胞趋化缺陷。基于对其血清和正常人血清的后续研究，已鉴定出一种白细胞趋化抑制剂。这种抑制剂被称为细胞定向抑制剂（CDI），相对耐热且不可透析。通过在蔗糖密度梯度中进行超速离心分析，该抑制剂已被解析为两种活性成分，估计沉降系数分别为7S和10S。它直接与中性粒细胞和单核细胞相互作用，使其趋化功能出现缺陷。CDI还会损害中性粒细胞的吞噬功能。有证据表明正常血清中存在该抑制剂的拮抗剂。CDI及其拮抗剂可能是正常存在的白细胞趋化调节因子。在所研究的患者中，CDI血清水平升高可能与李斯特菌感染的发生以及皮肤对皮肤试验抗原的反应失败有关。
